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19 August 2021: Lab/In Vitro Research

Hyperglycemia Promotes Liver Metastasis of Colorectal Cancer via Upregulation of Integrin αvβ6

Ben Wang 1ABEG , Shanjie Wang 2B , Wenke Wang 3BC , Enyu Liu 1BD , Sen Guo 1EF , Chuanzong Zhao 1CF , Jun Niu 1AD* , Zongli Zhang 1A*

DOI: 10.12659/MSM.930921

Med Sci Monit 2021; 27:e930921

Figure 3 High glucose induced upregulation of integrin β6. HT-29 and WiDr cells were incubated with medium containing various concentrations of glucose for 24 h, and expression of integrin β6 and αv was measured by real-time PCR (A, B) and western blot (C, D). (E) Expression of integrin β1, β3, and β5 was detected by real-time PCR in HT-29 cells. Mean±SD of 3 independent experiments. * P<0.05 vs control. OC – osmotic control; NG – normal glucose; HG – high glucose.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750