19 August 2021 : Laboratory Research
Hyperglycemia Promotes Liver Metastasis of Colorectal Cancer via Upregulation of Integrin αvβ6
Ben Wang1ABEG, Shanjie Wang2B, Wenke Wang3BC, Enyu Liu1BD, Sen Guo1EF, Chuanzong Zhao1CF, Jun Niu1AD, Zongli Zhang1A*DOI: 10.12659/MSM.930921
Med Sci Monit 2021; 27:e930921
Figure 7 Diabetes promoted liver metastasis through integrin αvβ6 in the mouse model. (A) Liver metastasis was induced by intrasplenic injection of CT26 cells. (B) The number of liver metastatic nodules in each group is shown. (C) Protein expression of β6 was detected by western blot. * P<0.05 vs control. # P<0.05 vs DM. DM – diabetic mice; DM+MET – diabetic mice treated with oral administration of metformin; DM+sh-β6 – diabetic mice treated by injection of β6 shRNA.