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19 August 2021: Lab/In Vitro Research

Hyperglycemia Promotes Liver Metastasis of Colorectal Cancer via Upregulation of Integrin αvβ6

Ben Wang 1ABEG , Shanjie Wang 2B , Wenke Wang 3BC , Enyu Liu 1BD , Sen Guo 1EF , Chuanzong Zhao 1CF , Jun Niu 1AD* , Zongli Zhang 1A*

DOI: 10.12659/MSM.930921

Med Sci Monit 2021; 27:e930921

Figure 7 Diabetes promoted liver metastasis through integrin αvβ6 in the mouse model. (A) Liver metastasis was induced by intrasplenic injection of CT26 cells. (B) The number of liver metastatic nodules in each group is shown. (C) Protein expression of β6 was detected by western blot. * P<0.05 vs control. # P<0.05 vs DM. DM – diabetic mice; DM+MET – diabetic mice treated with oral administration of metformin; DM+sh-β6 – diabetic mice treated by injection of β6 shRNA.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750