Knockout of the Cannabinoid Receptor 2 Gene Promotes Inflammation and Hepatic Stellate Cell Activation by Promoting A20/Nuclear Factor-κB (NF-κB) Expression in Mice with Carbon Tetrachloride-Induced Liver Fibrosis

Cuizhen Long; Na Xie; Yuanhui Shu; Yafeng Wu; Ping He; Yan Zhou; Yining Xiang; Junying Gu; Lei Yang; Yuping Wang

doi:10.12659/MSM.931236

20 August 2021 : Animal Research

Knockout of the Cannabinoid Receptor 2 Gene Promotes Inflammation and Hepatic Stellate Cell Activation by Promoting A20/Nuclear Factor-κB (NF-κB) Expression in Mice with Carbon Tetrachloride-Induced Liver Fibrosis

Cuizhen Long^123ABCDEF, Na Xie^12ABCDEF, Yuanhui Shu^12ABCF, Yafeng Wu^14ABCF, Ping He^12BC, Yan Zhou^12BC, Yining Xiang^5CD, Junying Gu^12CD, Lei Yang^12DF, Yuping Wang^12ABCDEFG*

DOI: 10.12659/MSM.931236

Med Sci Monit 2021; 27:e931236

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Figure 4 (A, B) Expression of α-SMA and TGF-β1 in liver tissue of 4 groups. Deletion of cannabinoid receptor 2 promoted the activation of HSCs. α-SMA, α-smooth muscle actin; TGF-β1, transforming growth factor-β1. # P<0.05 compared with the WT control group, * P<0.05 compared with the CB2−/− control group, and & P<0.05 compared with the WT model group.

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Knockout of the Cannabinoid Receptor 2 Gene Promotes Inflammation and Hepatic Stellate Cell Activation by Promoting A20/Nuclear Factor-κB (NF-κB) Expression in Mice with Carbon Tetrachloride-Induced Liver Fibrosis

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