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19 June 2021: Review Articles

A Review of Neurological Involvement in Patients with SARS-CoV-2 Infection

Yidan Xu 12EF* , Yu Zhuang 12EF* , Lumei Kang 13AG*

DOI: 10.12659/MSM.932962

Med Sci Monit 2021; 27:e932962

Figure 2 Neuroinflammation in the CNSA. Hypoxia. Inadequate oxygen supply to the brain leads to ATP crisis and exacerbated inflammatory state. B. Demyelination. A leaky BBB allows the entrance of virus and peripheral lymphocytes into the CNS, resulting in activation of microglia. Reactivated microglia release inflammatory cytokines (TNF-α and IL-6), contributing to demyelination and neuron death. C. Oligodendrocyte apoptosis. Infiltrating neutrophils adversely impact neuronal function by inducing oligodendrocyte apoptosis. (Created with BioRender.com).

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750