10 October 2021 : Animal Research
Pretreatment with Methylene Blue Protects Against Acute Seizure and Oxidative Stress in a Kainic Acid-Induced Status Epilepticus Model
Yong-feng Wang1E, Yan Luo2C, Gao-lei Hou1B, Rui-jing He3C, Hao-yun Zhang3F, Yan-Li Yi3D, Ying Zhang3B, Zhi-qiang Cui3AG*DOI: 10.12659/MSM.933469
Med Sci Monit 2021; 27:e933469

Figure 1 Chemical structure and redox balance of methylene blue (MB). MB has powerful autoxidizable properties. It can accept electrons from an electron donor in its oxidized form and acts as an electron donor in its reduced form. At low concentrations in vivo, the 2 forms of MB are at equilibrium, forming a reversible reduction-oxidation system.