Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

10 October 2021: Animal Study

Pretreatment with Methylene Blue Protects Against Acute Seizure and Oxidative Stress in a Kainic Acid-Induced Status Epilepticus Model

Yong-feng Wang 1E* , Yan Luo 2C* , Gao-lei Hou 1B , Rui-jing He 3C , Hao-yun Zhang 3F , Yan-Li Yi 3D , Ying Zhang 3B , Zhi-qiang Cui 3AG*

DOI: 10.12659/MSM.933469

Med Sci Monit 2021; 27:e933469

Figure 4 Effect of methylene blue (MB) on kainic acid (KA)-induced epileptiform activity in vivo. (A) Representative tracings showing KA-induced epileptiform activity for the full recording period in vivo in mice pretreated with vehicle, 0.5 mg/kg of MB, and 1 mg/kg of MB, respectively. Electroencephalogram tracings are labeled to indicate drug administration times (vehicle, MB, and KA) accordingly. Histograms showing the latency (minutes) (B), average epileptiform duration (minutes) (C), and epileptiform activity (percentage) (D) of epileptiform activity in KA-treated mice in different group. Values are expressed as means┬▒standard error of the mean. (n=11 vehicle+KA group, n=12 MB 0.5 mg/kg or 1 mg/kg+KA group). # P<0.05 vs vehicle+KA group; & P<0.05 vs MB 0.5 mg/kg+KA group. (Prism 8, version 8.3.0).

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750