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10 October 2021: Animal Study

Pretreatment with Methylene Blue Protects Against Acute Seizure and Oxidative Stress in a Kainic Acid-Induced Status Epilepticus Model

Yong-feng Wang 1E* , Yan Luo 2C* , Gao-lei Hou 1B , Rui-jing He 3C , Hao-yun Zhang 3F , Yan-Li Yi 3D , Ying Zhang 3B , Zhi-qiang Cui 3AG*

DOI: 10.12659/MSM.933469

Med Sci Monit 2021; 27:e933469

Figure 5 Effect of methylene blue (MB) on levels of hippocampus (A) malondialdehyde, (B) superoxide dismutase, and (C) glutathione 3 h after kainic acid (KA) administration. Values are expressed as means┬▒standard error of the mean. (n=11 vehicle+KA group, n=12 MB 0.5 mg/kg or 1 mg/kg+KA group) * P<0.05 vs control group; # P<0.05 vs KA or vehicle+KA group; & P<0.05 vs MB 0.5 mg/kg+KA group. (Prism 8, version 8.3.0).

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750