Pretreatment with Methylene Blue Protects Against Acute Seizure and Oxidative Stress in a Kainic Acid-Induced Status Epilepticus Model

Yong-feng Wang; Yan Luo; Gao-lei Hou; Rui-jing He; Hao-yun Zhang; Yan-Li Yi; Ying Zhang; Zhi-qiang Cui

doi:10.12659/MSM.933469

10 October 2021 : Animal Research

Pretreatment with Methylene Blue Protects Against Acute Seizure and Oxidative Stress in a Kainic Acid-Induced Status Epilepticus Model

Yong-feng Wang^1E, Yan Luo^2C, Gao-lei Hou^1B, Rui-jing He^3C, Hao-yun Zhang^3F, Yan-Li Yi^3D, Ying Zhang^3B, Zhi-qiang Cui^3AG*

DOI: 10.12659/MSM.933469

Med Sci Monit 2021; 27:e933469

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Figure 6 Effect of methylene blue (MB) on levels of (A) glutamate (Glu), (B) gamma-aminobutyric acid (GABA), and (C) Glu/GABA in kainic acid (KA)-treated mice. Values are expressed as means±standard error of the mean. (n=11 vehicle+KA group, n=12 MB 0.5 or 1 mg/kg+KA group) * P<0.05 vs control group; # P<0.05 vs KA group or MB 0.5 mg/kg+KA group or vehicle+KA group. (Prism 8, version 8.3.0).

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Pretreatment with Methylene Blue Protects Against Acute Seizure and Oxidative Stress in a Kainic Acid-Induced Status Epilepticus Model

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