Figure 1 The characteristics of Adie’s pupils. (A) Under natural light, the pupil on the left is significantly larger than the pupil on the right. (B) After 0.125% pilocarpine is applied in both eyes, the left pupil shows obvious contraction; however, the right pupil remains unchanged. (C) On exposure of the left pupil to a flashlight, it remains unchanged, while the right pupil contracts significantly; that is, the direct reflection of light from the left pupil is absent, and the indirect reflection from the right pupil exists. (D) On exposure of the right pupil to the flashlight, it contracts significantly, while the left pupil does not change; that is, direct reflection of light from the right pupil exists, and indirect reflection from the left pupil is absent. The sun symbol represents natural light; the water drop symbol represents the use of pilocarpine applied in the eyes; the flashlight symbol represents the light reflection from the pupil.