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23 April 2022: Clinical Research

Combining Magnetic Resonance Diffusion-Weighted Imaging with Prostate-Specific Antigen to Differentiate Between Malignant and Benign Prostate Lesions

Liying Han 1CEF , Guanyong He 1CDE , Yingjie Mei 2CD , Qing Yu 3BF , Minning Zhao 3BF , Fu Luo 4B , Guanxun Cheng 1AEG** , Wen Liang 3AE**

DOI: 10.12659/MSM.935307

Med Sci Monit 2022; 28:e935307

Figure 2 Magnetic resonance images of a 76-year-old patient with benign prostatic hyperplasia and chronic inflammation, total prostate-specific antigen (PSA) of 20.40 ng/mL, free/total PSA of 0.117, and PSA density of 0.19 ng/ml/cm3. The axial T2-weighted imaging (A) exhibits a circular hypointensity nodule with a clear boundary located at the left anterior of the transitional zone (white arrow). The nodule appears as a slightly high signal change (B, white arrow) on diffusion-weighted imaging and a slightly low signal on apparent diffusion coefficient (ADC) (C, white arrow). The pseudo-color maps of D (D), Dapp (G), and Kapp (H) show the lesion clearly (white arrow). The image quality of f (E) and D* (F) are unsatisfactory. The parameter values of the lesion are 0.93×10−3 mm2/s (ADC), 1.05×10−3 mm2/s (D), 0.12 (f), 101.72×10−3 mm2/s (D*), 1.57×10−3 mm2/s (Dapp), and 0.88 (Kapp). The prediction probability (P) of the lesion being cancer can be calculated as follows:P=e(4.339+3.896×0.19-7.130×0.93)1+e(4.339+3.896×0.19-7.130×0.93)=17.5%. (Ingenia 3.0T,PHILIPS;PRIDE DWI Tool 1.5,PHILIPS;Image J 1.52a,NIH).

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750