Figure 5 Gene set enrichment analysis and gene mutation analysis of the 2 risk groups. (A) The Kyoto Encyclopedia of Genes and Genomes enrichment results (top 5) in the low- and (B) high-risk groups (P<0.05). (C) The top 10 significantly mutated genes in the mutated EAC samples of the low- and (D) high-risk groups. (E) The difference in TMB in the 2 risk groups (ns – not significant). (F) Correlation analysis between the risk score and TMB. EAC – esophageal adenocarcinoma; TMB – tumor mutation burden.