04 August 2023>: Clinical Research
Impact of Coexisting Risk Factors on Outcomes in Patients with Acute Coronary Syndrome: A Real-World Analysis Using the Taiwan Chang Gung Research Database
Wei-Chieh Lee 1234ABCDEG** , Po-Jui Wu 3AG , Yi-Hsuan Tsai 5CD , Yun-Yu Hsieh 5CD , Tien-Yu Chen 5F , Yen-Nan Fang 3F , Huang-Chung Chen 3F , Hsiu-Yu Fang 36F**DOI: 10.12659/MSM.941258
Med Sci Monit 2023; 29:e941258
Figure 1 Kaplan-Meier curve analysis and hazard ratios (HRs) for gastrointestinal (GI) bleeding in patients with acute coronary syndrome (ACS) and a combination of diabetes mellitus (DM), chronic kidney disease (CKD), or advanced age during the 3-year follow-up period. (A) Kaplan-Meier curve analysis for GI bleeding between the ACS population with DM, CKD, or advanced age, or the combination of 2 or 3 risk factors (log-rank P<0.001). (B) In patients with 1 risk factor (DM, CKD, or elderly age), the HR of GI bleeding was 1.87 (95% CI: 1.48–2.35; P<0.001), 3.39 (95% CI: 2.74–4.18; P<0.001), and 4.33 (95% CI: 3.42–5.50; P<0.001), respectively. In patients with a combination of 2 risk factors, the HR of GI bleeding was 6.83 (95% CI: 5.26–8.86; P<0.001) for elderly age plus DM, 3.39 (95% CI: 6.58–9.60; P<0.001) for CKD plus elderly age, 6.21 (95% CI: 5.17–7.45; P<0.001) for CKD plus DM. In elderly patients with DM and CKD, HR of GI bleeding was 11.32 (95% CI: 9.41–13.61; P<0.001) during the 3-year follow-up period.