04 August 2023>: Clinical Research
Impact of Coexisting Risk Factors on Outcomes in Patients with Acute Coronary Syndrome: A Real-World Analysis Using the Taiwan Chang Gung Research Database
Wei-Chieh Lee 1234ABCDEG** , Po-Jui Wu 3AG , Yi-Hsuan Tsai 5CD , Yun-Yu Hsieh 5CD , Tien-Yu Chen 5F , Yen-Nan Fang 3F , Huang-Chung Chen 3F , Hsiu-Yu Fang 36F**DOI: 10.12659/MSM.941258
Med Sci Monit 2023; 29:e941258
Figure 4 Kaplan-Meier curve analysis and hazard ratios (HRs) for all-cause mortality in patients with acute coronary syndrome (ACS) and a combination of diabetes mellitus (DM), or chronic kidney disease (CKD), or advanced age during the 3-year follow-up period. (A) Kaplan-Meier curve analysis for all-cause mortality between the ACS population with DM, CKD, or advanced age, or the combination of 2 or 3 risk factors (log-rank P<0.001). (B) In patients with 1 risk factor (DM, CKD, or advanced age), HR of all-cause mortality was 1.37 (95% CI: 1.23–1.52; P<0.001), 3.92 (95% CI: 3.60–4.27; P<0.001), and 5.05 (95% CI: 4.60–5.55; P<0.001), respectively. In the patients with a combination of two risk factors, HR of all-cause mortality was 5.30 (95% CI: 4.72–5.95; P<0.001) for advanced age plus DM, 8.27 (95% CI: 7.66–8.94; P<0.001) for CKD plus advanced age, and 4.75 (95% CI: 4.39–5.15; P<0.001) for CKD plus DM. In elderly patients with DM and CKD, the HR of CV mortality was 8.59 (95% CI: 7.94–9.30; P<0.001) during the 3-year follow-up period.