06 March 2024>: Clinical Research
Molecular Determinants of Drug Resistance and Mutation Patterns in Influenza Viruses Circulating in Poland Across Multiple Epidemic Seasons: Implications for Vaccination Strategies
Ewelina Hallmann 1ABDEFG* , Aleksander Masny 1AD , Anna Poznańska 2CD , Francisco Pozo 34A , Inmaculada Casas 34A , Lidia Bernadeta Brydak 1ADDOI: 10.12659/MSM.942125
Med Sci Monit 2024; 30:e942125
Figure 1 Structure of neuraminidase A/Brisbane/02/2018 (A/H1N1/pdm09) with the R77G mutation detected in clinical sample number 145, as an example of a “viral oligomerization interface” mutation. The location of the mutation corresponds to position 77 of the B subunit chain (yellow backbone) and is 5 Ångström (A) from the A subunit oligomeric chain (blue backbone) in the A/H1N1/pdm09 neuraminidase gene (created using the FluSurver mutations app – https://gisaid.org/database-features/flusurver-mutations-app/).