06 March 2024: Clinical Research
Molecular Determinants of Drug Resistance and Mutation Patterns in Influenza Viruses Circulating in Poland Across Multiple Epidemic Seasons: Implications for Vaccination Strategies
Ewelina Hallmann 1ABDEFG* , Aleksander Masny 1AD , Anna Poznańska 2CD , Francisco Pozo 34A , Inmaculada Casas 34A , Lidia Bernadeta Brydak 1ADDOI: 10.12659/MSM.942125
Med Sci Monit 2024; 30:e942125
Figure 2 Structure of the neuraminidase of the virus B/Phuket/3073/2013 with the D356H mutation detected in clinical sample number 203, as an example of a mutation with the property of drug binding. The location of the mutation corresponds to position 224 of the A chain (yellow backbone) and is 5 Ångström (A) from the drug-binding site (created using the FluSurver mutations app – https://gisaid.org/database-features/flusurver-mutations-app/).