Molecular Determinants of Drug Resistance and Mutation Patterns in Influenza Viruses Circulating in Poland Across Multiple Epidemic Seasons: Implications for Vaccination Strategies

Ewelina Hallmann; Aleksander Masny; Anna Poznańska; Francisco Pozo; Inmaculada Casas; Lidia Bernadeta Brydak

doi:10.12659/MSM.942125

06 March 2024 : Clinical Research

Molecular Determinants of Drug Resistance and Mutation Patterns in Influenza Viruses Circulating in Poland Across Multiple Epidemic Seasons: Implications for Vaccination Strategies

Ewelina Hallmann

^1ABDEFG*, Aleksander Masny

^1AD, Anna Poznańska

^2CD, Francisco Pozo

^34A, Inmaculada Casas^34A, Lidia Bernadeta Brydak

^1AD

DOI: 10.12659/MSM.942125

Med Sci Monit 2024; 30:e942125

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Figure 4 An example of a mutation site related to antibody-binding properties: the K369N mutation in the neuraminidase gene of virus A/Brisbane/02/2018 (A/H1N1/pdm09) in clinical sample number 770. The location of the mutation (red) corresponds to position 369 on the viral N chain (yellow backbone) and is 5 Ångström (A) from the heavy chain (H) antibodies (purple skeleton) (created using the FluSurver mutations app – https://gisaid.org/database-features/flusurver-mutations-app/).

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Molecular Determinants of Drug Resistance and Mutation Patterns in Influenza Viruses Circulating in Poland Across Multiple Epidemic Seasons: Implications for Vaccination Strategies

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