06 March 2024: Clinical Research
Molecular Determinants of Drug Resistance and Mutation Patterns in Influenza Viruses Circulating in Poland Across Multiple Epidemic Seasons: Implications for Vaccination Strategies
Ewelina Hallmann 1ABDEFG* , Aleksander Masny 1AD , Anna Poznańska 2CD , Francisco Pozo 34A , Inmaculada Casas 34A , Lidia Bernadeta Brydak 1ADDOI: 10.12659/MSM.942125
Med Sci Monit 2024; 30:e942125
Figure 5 Host protein-binding site exemplified by the G451R mutation in the neuraminidase gene of virus A/SingaporeINFIMH-16-0019/2016 (A/H3N2/) in clinical sample number 229. The location of the mutation corresponds to position 452 of the viral F chain (yellow backbone) of the neuraminidase gene and is 5 Ångström (A) from the D-chain of a non-viral protein (blue backbone), in this case the MHC class I antigen. The white backbone represents the other chains found in the structure (created using the FluSurver mutations app – https://gisaid.org/database-features/flusurver-mutations-app/).