21 November 2023 : Review article
Circadian Rhythms in Cardiovascular Function: Implications for Cardiac Diseases and Therapeutic Opportunities
Jiayue Lin
12EF, Haoming Kuang1F, Jiahao Jiang 3BF, Hui Zhou 4A, Li Peng2B, Xu Yan 2AE*, Jianjun Kuang5EF
DOI: 10.12659/MSM.942215
Med Sci Monit 2023; 29:e942215
Figure 1 The molecular mechanism of the circadian clock in mammals. Constituting the core circadian clock is an autoregulatory transcriptional feedback loop involving the activators CLOCK and BMAL1 and their target genes Per1, Per2, Cry1, and Cry2, whose gene products form a negative-feedback repressor complex.