21 November 2023: Review Articles
Circadian Rhythms in Cardiovascular Function: Implications for Cardiac Diseases and Therapeutic Opportunities
Jiayue Lin 12EF* , Haoming Kuang 1F* , Jiahao Jiang 3BF , Hui Zhou 4A , Li Peng 2B , Xu Yan 2AE* , Jianjun Kuang 5EF*DOI: 10.12659/MSM.942215
Med Sci Monit 2023; 29:e942215
Figure 1 The molecular mechanism of the circadian clock in mammals. Constituting the core circadian clock is an autoregulatory transcriptional feedback loop involving the activators CLOCK and BMAL1 and their target genes Per1, Per2, Cry1, and Cry2, whose gene products form a negative-feedback repressor complex.