Targeting MuRF1 to Combat Skeletal Muscle Wasting in Cardiac Cachexia: Mechanisms and Therapeutic Prospects

Xiaotong Liu; Ya Wen; Yanmei Lu

doi:10.12659/MSM.945211

22 October 2024 : Review article

Targeting MuRF1 to Combat Skeletal Muscle Wasting in Cardiac Cachexia: Mechanisms and Therapeutic Prospects

Xiaotong Liu^1E, Ya Wen^2E, Yanmei Lu

^1A*

DOI: 10.12659/MSM.945211

Med Sci Monit 2024; 30:e945211

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Introduction Pathophysiological Mechanism of Cardiac Cachexia Alterations in Hormone Levels Excessive Inflammatory Responses Unbalanced Protein Synthesis and Degradation Structure and Functions of MuRF1 Development of Related Inhibitors Targeting MuRF1 Discussion References

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Figure 1 Cardiac cachexia represents an advanced stage of CHF characterized by systemic decline and metabolic dysfunction. This condition leads to profound nutrition depletion and a catabolic state, manifesting as anorexia, progressive weakness, emaciation, pronounced cheekbones, hollow eye sockets, a pallid complexion, and skeletal muscle atrophy. Produced using Procreate® developed by Savage Interactive Pty Ltd.(version5.2.6).

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Targeting MuRF1 to Combat Skeletal Muscle Wasting in Cardiac Cachexia: Mechanisms and Therapeutic Prospects

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