Targeting MuRF1 to Combat Skeletal Muscle Wasting in Cardiac Cachexia: Mechanisms and Therapeutic Prospects

Xiaotong Liu; Ya Wen; Yanmei Lu

doi:10.12659/MSM.945211

22 October 2024 : Review article

Targeting MuRF1 to Combat Skeletal Muscle Wasting in Cardiac Cachexia: Mechanisms and Therapeutic Prospects

Xiaotong Liu^1E, Ya Wen^2E, Yanmei Lu

^1A*

DOI: 10.12659/MSM.945211

Med Sci Monit 2024; 30:e945211

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Introduction Pathophysiological Mechanism of Cardiac Cachexia Alterations in Hormone Levels Excessive Inflammatory Responses Unbalanced Protein Synthesis and Degradation Structure and Functions of MuRF1 Development of Related Inhibitors Targeting MuRF1 Discussion References

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Figure 2 Wasting in CHF. CHF leads to a variety of pathological and physiological changes, causing continuous consumption of the body, resulting in skeletal muscle wasting, loss of bone mineral density, wasting to adipose tissue, and even leading to cachexia. Cachexia can also, in turn, promote more severe consumption. Produced using BioRender.com developed by BioRender Ltd.

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Targeting MuRF1 to Combat Skeletal Muscle Wasting in Cardiac Cachexia: Mechanisms and Therapeutic Prospects

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