21 January 2026 : Review article
Role of Oxysterol-Binding Protein Family in Cholesterol Metabolism and Cancer Progression: A Review
Yu Wu ABCDEF 1, Xinhui Lv BC 1, Jiyuan Yang BC 1, Sicong Liu C 1, Yafang Chen A 1, Ziwen Yuan F 1, Xudong Wang AEG 2*DOI: 10.12659/MSM.949032
Med Sci Monit 2026; 32:e949032
Figure 1 Oxysterol-binding protein–related protein (ORP) 5/8-mediated phosphatidylserine (PS) and phosphatidylinositol-4-phosphate (PI4P) exchange over endoplasmic reticulum (ER)-plasma membrane (PM) contacts is displayed. ORP5 and ORP8 facilitate the enrichment of PS at the ER by exchanging it for PI4P, which is subsequently dephosphorylated by the ER-localized phosphatase Sac1 [75]. The recruitment of ORP5/8 to the PM is mediated by interactions between their pleckstrin homology (PH) and phosphoinositide-binding domains with PI4P and phosphatidylinositol 4,5-bisphosphate (PI[4,5]P2). This figure has been modified from a previous publication by Santo. The software used to create this diagram was WPS [76].