28 June 2010
Value of exercise testing to estimate post-operative complications and mortality in solid organ recipients: A preliminary study
Gaye Ulubay, Sevinc Sarinc Ulasli, Elif Küpeli, Eylul Bozkurt Yilmaz, Atilla Sezgin, Mehmet HaberalAnn Transplant 2010; 15(2): 11-20 :: ID: 880935
Abstract
Background: The pre-operative pulmonary risk assessment of solid organ transplant recipients is crucial to decrease post-operative pulmonary mortality and morbidity. Spirometry is the most commonly utilized test to predict post-operative pulmonary complications. This study was performed to evaluate the role of Cardiopulmonary Exercise Testing (CPET) in both heart and kidney transplantation recipients.
Material/Methods: Patients referred for pulmonary evaluation between August 2008 and June 2009 prior to solid organ transplantation were included in this study. Patients’ history, demographics, and physical examination were recorded. All patients performed pulmonary function tests (PFTs) and symptom-limited CPET. Thirty-four subjects (21 with heart failure and 16 with chronic renal failure) awaiting solid organ transplantation were enrolled to this study prospectively.
Results: No pulmonary complication was found in the renal transplantation recipients, and there were pulmonary complications in 10 heart transplantation recipients. There was no difference between spirometric parameters with post-operative early pulmonary complications and mortality (p>0.05) in heart and kidney transplantation recipients. Anaerobic threshold oxygen uptake (VO2@AT) was significantly decreased, while minute ventilation to carbon dioxide output (VE/VCO2@AT) was increased in heart recipients (p<0.05).
Conclusions: CPET parameters measured at anaerobic threshold could help predict surgical mortality and pulmonary complications following heart transplantation. However, our study demonstrated that CPET parameters could not predict post-operative mortality and pulmonary complications in renal recipients. Therefore, heart transplant candidates should be routinely evaluated with CPET and spirometry to estimate post-operative early mortality and pulmonary complications pre-operatively.
Keywords: Cardiopulmonary exercise testing, post-operative, pulmonary complications, solid organs recipients
In Press
20 Mar 2024 : Original article
Transplant Nephrectomy: A Comparative Study of Timing and Techniques in a Single InstitutionAnn Transplant In Press; DOI: 10.12659/AOT.942252
28 Mar 2024 : Original article
Association Between FEV₁ Decline Rate and Mortality in Long-Term Follow-Up of a 21-Patient Pilot Clinical T...Ann Transplant In Press; DOI: 10.12659/AOT.942823
02 Apr 2024 : Original article
Liver Transplantation from Brain-Dead Donors with Hepatitis B or C in South Korea: A 2014-2020 Korean Organ...Ann Transplant In Press; DOI: 10.12659/AOT.943588
02 Apr 2024 : Original article
Effect of Dexmedetomidine Combined with Remifentanil on Emergence Agitation During Awakening from Sevoflura...Ann Transplant In Press; DOI: 10.12659/AOT.943281
Most Viewed Current Articles
05 Apr 2022 : Original article
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
12 Jan 2022 : Original article
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
22 Nov 2022 : Original article
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860