11 December 2020 : Clinical Research
The Predictive Value of the Follicular Output Rate on Pregnancy Outcome of Patients with Polycystic Ovary Syndrome Undergoing In Vitro Fertilization and Embryo Transfer
Haiyan Yang1ABCEF, Jia Lin1ABE, Congcong Jin1BCF, Lvhe Meng1CDF, Suichun Wu1CDE, Ya Chen1ABDEG*DOI: 10.12659/MSM.916175
Med Sci Monit 2020; 26:e916175
Table 3 Baseline characteristics, ovarian stimulation data and IVF/ICSI outcomes in the low, medium and high FORT groups.
| Low FORT (n=516) | Medium FORT (n=529) | High FORT (n=496) | P-value | |
|---|---|---|---|---|
| Age | 29.33±3.57 | 29.38±3.45 | 29.39±3.67 | 0.799 |
| Duration of infertility (year) | 3.99±2.53 | 3.84±2.44 | 3.99±2.62 | 0.969 |
| Body mass index (kg/m) | 23.06±3.50 | 23.34±3.74 | 22.36±3.34 | 0.080 |
| Day 3 follicle-stimulating hormone (IU/L) | 6.66±1.57 | 6.59±1.56 | 6.64±1.61 | 0.837 |
| Day 3 oestradiol (pg/ml) | 31.08±8.19 | 31.10±8.14 | 30.96±8.09 | 0.689 |
| Antral follicle count | 31.63±10.05 | 26.95±8.30 | 22.70±6.86 | 0.000 |
| Pre-ovulatory follicle count | 3.79±1.51 | 6.12±1.96 | 9.30±3.06 | 0.000 |
| Stimulation days | 12.34±3.39 | 12.07±3.09 | 11.78±2.83c | 0.047 |
| Total follicle-stimulating hormone amount (IU) | 1660.98±811.07 | 1654.12±835.76 | 1562.72±684.88c | 0.000 |
| Serum oestradiol on human chorionic gonadotrop day (pg/ml) | 2981.59±1793.93 | 3421.62±1841.81 | 4036.08±1984.99 | 0.000 |
| Retrieved oocyte | 14.31±7.41 | 14.98±7.60b | 16.58±7.37 | 0.000 |
| MII oocyte | 12.53±6.67a | 13.46±7.09 | 14.96±6.85 | 0.000 |
| Fertilized oocyte | 9.01±5.28 | 9.66±5.55b | 10.71±5.55 | 0.000 |
| Fertilization rate (%) | 72.05±19.17 | 71.97±19.01 | 72.01±18.98 | 0.921 |
| Total number of embryos | 8.31±5.35 | 8.91±5.46b | 9.97±5.56 | 0.000 |
| Number of high quality embryos | 4.61±3.91 | 4.84±3.69b | 5.47±4.04 | 0.000 |
| Number of transferred embryos in fresh-embryo cycle | 2.01±0.28 | 2.01±0.22 | 2.00±0.21 | 0.879 |
| Clinical pregnancy rate of fresh-embryo transfer (%) | 65.44 (267/408) | 64.07 (230/359) | 64.29 (189/294) | 0.379 |
| Pregnancy loss rate of fresh-embryo transfer (%) | 19.10 (51/267) | 16.52 (38/230) | 21.16 (40/189) | 0.229 |
| Live birth rate of fresh-embryos transfer (%) | 51.96 (212/408) | 52.65 (189/359) | 49.32 (145/294) | 0.179 |
| Freeze-all rate (%) | 20.93 (108/516) | 32.14 (170/529) | 40.73 (202/496) | 0.000 |
| Number of frozen embryo transfer cycle | 276 | 311 | 370 | – |
| Clinical pregnancy rate of frozen-embryo transfer (%) | 56.88 (157/276) | 52.09 (162/311) | 58.11 (215/370) | 0.149 |
| Pregnancy loss rate of frozen-embryos transfer (%) | 19.11 (30/157) | 19.14 (31/162) | 11.37 (24/211) | 0.459 |
| Live birth rate of frozen-embryo transfer (%) | 43.48 (120/276) | 40.84 (127/311)b | 51.35 (190/370)c | 0.016 |
| Cumulative live birth rate (%) | 64.34 (332/516) | 59.74 (316/529)b | 67.68 (335/496) | 0.032 |
| a and denotes b and denotes c and denotes | ||||