24 June 2020>: Clinical Research
Comprehensive Analysis of Candidate Diagnostic and Prognostic Biomarkers Associated with Lung Adenocarcinoma
Jingyuan Li 1AE , Xingyuan Liu 23CF , Zan Cui 1B , Guanying Han 1DG*DOI: 10.12659/MSM.922070
Med Sci Monit 2020; 26:e922070
Table 5 TOP 5 GO function annotation of common uDEGs and dDEGs associated with LUAD.
Category | GO-ID | GO-term | Count | % | P-value |
---|---|---|---|---|---|
BP | GO: 0007067 | Mitotic nuclear division | 12 | 8.22 | 5.6E-06 |
BP | GO: 0006260 | DNA replication | 9 | 6.16 | 3.8E-05 |
BP | GO: 0000086 | G2/M transition of mitotic cell cycle | 8 | 5.48 | 1.3E-04 |
BP | GO: 0051301 | Cell division | 12 | 8.22 | 1.3E-04 |
BP | GO: 0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 6 | 4.11 | 1.4E-04 |
CC | GO: 0005634 | Nucleus | 53 | 36.30 | 4.5E-02 |
CC | GO: 0005737 | Cytoplasm | 52 | 35.62 | 3.6E-02 |
CC | GO: 0016324 | Apical plasma membrane | 8 | 5.48 | 7.9E-03 |
CC | GO: 0005813 | Centrosome | 8 | 5.48 | 4.9E-02 |
CC | GO: 0030496 | Midbody | 7 | 4.79 | 5.2E-04 |
MF | GO: 0005515 | Protein binding | 79 | 54.11 | 3.3E-02 |
MF | GO: 0005524 | ATP binding | 22 | 15.07 | 4.6E-03 |
MF | GO: 0042802 | Identical protein binding | 14 | 9.59 | 4.8E-03 |
MF | GO: 0004674 | Protein serine/threonine kinase activity | 9 | 6.16 | 8.3E-03 |
MF | GO: 0019901 | Protein kinase binding | 9 | 6.16 | 8.3E-03 |
BP | GO: 0045944 | Positive regulation of transcription from RNA polymerase II promoter | 45 | 10.47 | 2.6E-05 |
BP | GO: 0007165 | Signal transduction | 44 | 10.23 | 1.9E-03 |
BP | GO: 0007155 | Cell adhesion | 33 | 7.67 | 4.0E-08 |
BP | GO: 0001525 | Angiogenesis | 32 | 7.44 | 1.2E-15 |
BP | GO: 0000122 | Negative regulation of transcription from RNA polymerase II promoter | 30 | 6.98 | 3.2E-03 |
CC | GO: 0016021 | Integral component of membrane | 157 | 36.51 | 4.7E-05 |
CC | GO: 0005886 | Plasma membrane | 156 | 36.28 | 1.5E-11 |
CC | GO: 0070062 | Extracellular exosome | 80 | 18.60 | 3.3E-02 |
CC | GO: 0005887 | Integral component of plasma membrane | 71 | 16.51 | 8.2E-10 |
CC | GO: 0005576 | Extracellular region | 70 | 16.28 | 3.3E-07 |
MF | GO: 0005515 | Protein binding | 222 | 51.63 | 7.6E-03 |
MF | GO: 0005509 | Calcium ion binding | 28 | 6.51 | 6.2E-03 |
MF | GO: 0042803 | Protein homodimerization activity | 27 | 6.28 | 1.4E-02 |
MF | GO: 0046982 | Protein heterodimerization activity | 19 | 4.42 | 1.8E-02 |
MF | GO: 0008134 | Transcription factor binding | 18 | 4.19 | 2.5E-04 |
GO – Gene Ontology; uDEGs – upregulated differentially expressed genes; dDEGs – downregulated differentially expressed genes; LUAD – lung adenocarcinoma, BP – biological process, CC – cellular component MF – molecular function. |