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24 June 2020: Clinical Research

Comprehensive Analysis of Candidate Diagnostic and Prognostic Biomarkers Associated with Lung Adenocarcinoma

Jingyuan Li 1AE , Xingyuan Liu 23CF , Zan Cui 1B , Guanying Han 1DG*

DOI: 10.12659/MSM.922070

Med Sci Monit 2020; 26:e922070

Table 5 TOP 5 GO function annotation of common uDEGs and dDEGs associated with LUAD.

CategoryGO-IDGO-termCount%P-value
BPGO: 0007067Mitotic nuclear division128.225.6E-06
BPGO: 0006260DNA replication96.163.8E-05
BPGO: 0000086G2/M transition of mitotic cell cycle85.481.3E-04
BPGO: 0051301Cell division128.221.3E-04
BPGO: 0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest64.111.4E-04
CCGO: 0005634Nucleus5336.304.5E-02
CCGO: 0005737Cytoplasm5235.623.6E-02
CCGO: 0016324Apical plasma membrane85.487.9E-03
CCGO: 0005813Centrosome85.484.9E-02
CCGO: 0030496Midbody74.795.2E-04
MFGO: 0005515Protein binding7954.113.3E-02
MFGO: 0005524ATP binding2215.074.6E-03
MFGO: 0042802Identical protein binding149.594.8E-03
MFGO: 0004674Protein serine/threonine kinase activity96.168.3E-03
MFGO: 0019901Protein kinase binding96.168.3E-03
BPGO: 0045944Positive regulation of transcription from RNA polymerase II promoter4510.472.6E-05
BPGO: 0007165Signal transduction4410.231.9E-03
BPGO: 0007155Cell adhesion337.674.0E-08
BPGO: 0001525Angiogenesis327.441.2E-15
BPGO: 0000122Negative regulation of transcription from RNA polymerase II promoter306.983.2E-03
CCGO: 0016021Integral component of membrane15736.514.7E-05
CCGO: 0005886Plasma membrane15636.281.5E-11
CCGO: 0070062Extracellular exosome8018.603.3E-02
CCGO: 0005887Integral component of plasma membrane7116.518.2E-10
CCGO: 0005576Extracellular region7016.283.3E-07
MFGO: 0005515Protein binding22251.637.6E-03
MFGO: 0005509Calcium ion binding286.516.2E-03
MFGO: 0042803Protein homodimerization activity276.281.4E-02
MFGO: 0046982Protein heterodimerization activity194.421.8E-02
MFGO: 0008134Transcription factor binding184.192.5E-04
GO – Gene Ontology; uDEGs – upregulated differentially expressed genes; dDEGs – downregulated differentially expressed genes; LUAD – lung adenocarcinoma, BP – biological process, CC – cellular component MF – molecular function.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750