24 June 2020: Clinical Research
Comprehensive Analysis of Candidate Diagnostic and Prognostic Biomarkers Associated with Lung Adenocarcinoma
Jingyuan Li 1AE , Xingyuan Liu 23CF , Zan Cui 1B , Guanying Han 1DG*DOI: 10.12659/MSM.922070
Med Sci Monit 2020; 26:e922070
Table 7 KEGG pathway analysis of 3 key module in PPI network complex.
| ID | KEGG_PATHWAY | Count | % | P-value | Genes | |
|---|---|---|---|---|---|---|
| Module 1 | hsa04110 | Cell cycle | 6 | 21.43 | 1.3E-06 | CCNB1, CDK1, MAD2L1, CHEK1, CDC25C, MCM4 |
| hsa04115 | p53 signaling pathway | 5 | 17.86 | 3.8E-06 | CCNB1, CDK1, RRM2, CHEK1, GTSE1 | |
| hsa04114 | Oocyte meiosis | 5 | 17.86 | 2.9E-05 | CCNB1, CDK1, MAD2L1, AURKA, CDC25C | |
| Module 2 | hsa05200 | Pathways in cancer | 8 | 0.19 | 1.1E-04 | ADCY4, BMP2, CDKN2A, PPARG, CDH1, GNG2, GNG11, MMP1 |
| hsa04151 | PI3K-Akt signaling pathway | 6 | 0.14 | 3.2E-03 | CSF3, TEK, ANGPT1, GNG2, GNG11, SPP1 | |
| hsa05219 | Bladder cancer | 3 | 0.07 | 6.8E-03 | CDKN2A, CDH1, MMP1 | |
| Module 3 | hsa05217 | Basal cell carcinoma | 5 | 100.00 | 3.4E-09 | WNT7B, FZD1, AXIN2, FZD4, WNT2B |
| hsa04310 | Wnt signaling pathway | 5 | 100.00 | 1.6E-07 | WNT7B, FZD1, AXIN2, FZD4, WNT2B | |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells | 5 | 100.00 | 1.6E-07 | WNT7B, FZD1, AXIN2, FZD4, WNT2B | |
| KEGG – Kyoto Encyclopedia of Genes and Genomes; PPI – protein–protein interaction | ||||||