18 October 2020: Animal Study
Silencing of Long Non-Coding RNA X Inactive Specific Transcript (Xist) Contributes to Suppression of Bronchopulmonary Dysplasia Induced by Hyperoxia in Newborn Mice via microRNA-101-3p and the transforming growth factor-beta 1 (TGF-β1)/Smad3 Axis
Wenhao Yuan 1ABCDEF* , Xiaoyan Liu 1ABCDG* , Lingkong Zeng 1BCDFG* , Hanchu Liu 1ABCDEFG , Baohuan Cai 2ABCDEFG , Yanping Huang 1ABDF , Xuwei Tao 1ABCDF , Luxia Mo 1ABDF , Lingxia Zhao 1BCDF , Chunfang Gao 1BCDFDOI: 10.12659/MSM.922424
Med Sci Monit 2020; 26:e922424
Table 2 mRNA expression of lincRNA and its adjacent genes.
| Gene symbol | Fold change | Regulation | Gene symbol | Fold change | Regulation |
|---|---|---|---|---|---|
| Xist | 16.33 | Up | HMGB3 | 4.4 | Up |
| AK132645 | 9.43 | Up | Gsc | 3.13 | Up |
| AK087397 | 9.50 | Up | Slc35g3 | 2.86 | Down |
| Histlh2aj | 2.52 | Down | Histlh2bm | 2.61 | Down |
| Gm13644 | 2.13 | Down | Tmem88b | 2.4 | Up |
| lincRNA – long intergenic non-coding RNA; Xist – X inactive specific transcript; HMGB3 – high-mobility group protein 3. | |||||