Silencing of Long Non-Coding RNA X Inactive Specific Transcript (Xist) Contributes to Suppression of Bronchopulmonary Dysplasia Induced by Hyperoxia in Newborn Mice via microRNA-101-3p and the transforming growth factor-beta 1 (TGF-β1)/Smad3 Axis

Wenhao Yuan; Xiaoyan Liu; Lingkong Zeng; Hanchu Liu; Baohuan Cai; Yanping Huang; Xuwei Tao; Luxia Mo; Lingxia Zhao; Chunfang Gao

doi:10.12659/MSM.922424

18 October 2020 : Animal Research

Silencing of Long Non-Coding RNA X Inactive Specific Transcript (Xist) Contributes to Suppression of Bronchopulmonary Dysplasia Induced by Hyperoxia in Newborn Mice via microRNA-101-3p and the transforming growth factor-beta 1 (TGF-β1)/Smad3 Axis

Wenhao Yuan^1ABCDEF, Xiaoyan Liu^1ABCDG, Lingkong Zeng^1BCDFG*, Hanchu Liu^1ABCDEFG, Baohuan Cai^2ABCDEFG, Yanping Huang^1ABDF, Xuwei Tao^1ABCDF, Luxia Mo^1ABDF, Lingxia Zhao^1BCDF, Chunfang Gao^1BCDF

DOI: 10.12659/MSM.922424

Med Sci Monit 2020; 26:e922424

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Table 2 mRNA expression of lincRNA and its adjacent genes.

Gene symbol	Fold change	Regulation	Gene symbol	Fold change	Regulation
Xist	16.33	Up	HMGB3	4.4	Up
AK132645	9.43	Up	Gsc	3.13	Up
AK087397	9.50	Up	Slc35g3	2.86	Down
Histlh2aj	2.52	Down	Histlh2bm	2.61	Down
Gm13644	2.13	Down	Tmem88b	2.4	Up
lincRNA – long intergenic non-coding RNA; Xist – X inactive specific transcript; HMGB3 – high-mobility group protein 3.

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Silencing of Long Non-Coding RNA X Inactive Specific Transcript (Xist) Contributes to Suppression of Bronchopulmonary Dysplasia Induced by Hyperoxia in Newborn Mice via microRNA-101-3p and the transforming growth factor-beta 1 (TGF-β1)/Smad3 Axis

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