Bioinformatics for The Prognostic Value and Function of Cubilin (CUBN) in Colorectal Cancer

25 November 2020: Database Analysis

Yibin Wu ^BCDEF , Ye Xu ^ACG*

DOI: 10.12659/MSM.922447

Med Sci Monit 2020; 26:e922447

Table 1 Enrichment analysis of CUBN and its significant neighborhood genes altered in CRC as determined using DAVID.

Gene set	Description	Ontology	Count	P value
GO: 0042359	Vitamin D metabolic process	BP	3	9.6E-7
GO: 0051180	Vitamin transport	BP	2	8.9E-4
GO: 0042157	Lipoprotein metabolic process	BP	2	6.8E-3
GO: 0008203	Cholesterol metabolic process	BP	2	1.2E-2
GO: 0006898	Receptor-mediated endocytosis	BP	2	3.3E-2
GO: 0030139	Endocytic vesicle	CC	3	3.4E-5
GO: 0072562	Blood microparticle	CC	3	1.8E-4
GO: 0070062	Extracellular exosome	CC	5	5.8E-4
GO: 0034366	Spherical high-density lipoprotein particle	CC	2	2.2E-3
GO: 0042627	Chylomicron	CC	2	3.3E-3
GO: 0070653	High-density lipoprotein particle receptor binding	MF	2	1.3E-3
GO: 0008035	High-density lipoprotein particle binding	MF	2	2.0E-3
GO: 0060228	Phosphatidylcholine-sterol O-acyltransferase activator activity	MF	2	.6E-3
GO: 0017127	Cholesterol transporter activity	MF	2	5.3E-3
GO: 0031210	Phosphatidylcholine binding	MF	2	5.6E-3
hsa04977	Vitamin digestion and absorption	KP	2	0.006
GO – Gene Ontology; BP – biological process; CC – cellular component. MF; molecular function. KP – KEGG pathway.