13 June 2020 : Database Analysis
Comprehensive Analysis of Competing Endogenous RNA (ceRNA) Network Based on RNAs Differentially Expressed in Lung Adenocarcinoma Using The Cancer Genome Atlas (TCGA) Database
Huaihui Tang1ABCDEF, Zhongshuai Wang2F, Qianqian Shao3F, Yue Wang1FG, Qingshan Yang1AEG*DOI: 10.12659/MSM.922676
Med Sci Monit 2020; 26:e922676
Table 1 Results of mRNAs GO enrichment analysis in the ceRNA network.
| Category | Term | Count | Genes | FDR |
|---|---|---|---|---|
| MF | GO: 0043565~sequence-specific DNA binding | 33 | HOXA13, HOXA11, PAX3, NR2E1, HOXA1, HOXC8, LHX2, HOXA10, LHX5, POU4F1, FOXD1, NKX2-2, TLX1, PITX2, FOXL2, ERG, TBX3, OTX1, EMX2, HNF4G, EN2, NR4A3, FOXN4, SALL3, SHOX2, SALL4, HNF4A, HOXB7, SALL1, FOXG1, TFAP2B, TFAP2A, NEUROD1 | 9.42E-08 |
| MF | GO: 0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | 18 | FOXL2, ONECUT1, OTX1, NR4A3, HMGA2, MYBL2, NR2E1, HNF4A, HOXA10, TFAP2B, NEUROD1, TFAP2A, POU4F1, POU3F2, FOXD1, TLX1, KLF4, PITX2 | 3.98E-04 |
| MF | GO: 0003700~transcription factor activity, sequence-specific DNA binding | 35 | E2F2, E2F7, E2F8, PAX3, MYBL2, NR2E1, TAL1, HOXC8, PAX9, OVOL1, POU3F2, FOXD1, NKX2-2, PITX2, FOXL2, ERG, TBX3, RCOR2, OTX1, TBX4, HNF4G, HMGA1, FOXN4, MYCN, SALL3, DLX2, SALL4, HNF4A, HOXB7, SALL1, TFAP2B, NEUROD1, TFAP2A, TBX18, KLF4 | 0.017886388 |
| BP | GO: 0034765~regulation of ion transmembrane transport | 11 | KCNQ5, HCN2, KCNQ3, KCNJ6, SCN3A, CLIC5, CACNA1E, KCNJ10, SCN7A, KCNA7, KCNK10 | 0.027067873 |
| GO – Gene Ontology; mRNAs – messenger RNAs; ceRNAs – competing endogenous RNAs; MF – molecular function; BP – biological process. ( | ||||