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13 June 2020: Database Analysis

Comprehensive Analysis of Competing Endogenous RNA (ceRNA) Network Based on RNAs Differentially Expressed in Lung Adenocarcinoma Using The Cancer Genome Atlas (TCGA) Database

Huaihui Tang 1ABCDEF , Zhongshuai Wang 2F , Qianqian Shao 3F , Yue Wang 1FG , Qingshan Yang 1AEG*

DOI: 10.12659/MSM.922676

Med Sci Monit 2020; 26:e922676

Table 2 KEGG pathway analysis of mRNAs in the ceRNA network.

KEGG_PATHWAYhsa04110: Cell cycle118.30E-05CCNB1, CCNE2, CDK1, E2F2, CDC6, MAD2L1, BUB1, TTK, CHEK1, CCNA2, CDC25A
KEGG_PATHWAYhsa04512: ECM-receptor interaction91.76E-04IBSP, ITGA8, COL3A1, COL1A1, THBS2, COL5A2, COL5A1, THBS4, HMMR
KEGG_PATHWAYhsa04974: Protein digestion and absorption80.001086713COL9A1, COL3A1, MME, COL1A1, ATP1A2, SLC1A1, COL5A2, COL5A1
KEGG_PATHWAYhsa04950: Maturity onset diabetes of the young50.001173894HNF4A, ONECUT1, NEUROD1, HNF4G, NKX2-2
KEGG_PATHWAYhsa04151: PI3K-Akt signaling pathway140.01022117IBSP, FGF5, EFNA3, COL3A1, IL7R, COL5A2, COL5A1, CCNE2, G6PC, ITGA8, COL1A1, THBS2, PPP2R2C, THBS4
KEGG_PATHWAYhsa04914: Progesterone-mediated oocyte maturation60.021316139CCNB1, CDK1, MAD2L1, BUB1, CCNA2, CDC25A
KEGG_PATHWAYhsa05202: Transcriptional misregulation in cancer80.033242245ERG, HOXA10, NR4A3, HMGA2, IGFBP3, PLAU, TLX1, MYCN
KEGG_PATHWAYhsa04115: p53 signaling pathway50.033931086CCNB1, CCNE2, CDK1, CHEK1, IGFBP3
KEGG_PATHWAYhsa04510: Focal adhesion90.034922922IBSP, RASGRF1, ITGA8, COL3A1, COL1A1, THBS2, COL5A2, COL5A1, THBS4
KEGG_PATHWAYhsa04976: Bile secretion50.037228947SLCO1B3, LDLR, ABCC2, ATP1A2, ABCG2
KEGG – Kyoto Encyclopedia of Genes and Genomes; mRNAs – messenger RNAs; ceRNAs – competing endogenous RNAs. -value

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750