Estimation of Hub Genes and Infiltrating Immune Cells in Non-Smoking Females with Lung Adenocarcinoma by Integrated Bioinformatic Analysis

16 July 2020: Database Analysis

Jie Li ^1ABCDEF , Ben Wang ^2BCDF , Xin Li ^3BF , Yuxi Zhu ^1AE*

DOI: 10.12659/MSM.922680

Med Sci Monit 2020; 26:e922680

Table 1 GO and KEGG pathway enrichment analysis of 315 DEGs.

Term	Description	Gene count	P-value
GO-CC: 0005615	Extracellular space	64	1.21E-13
GO-CC: 0070062	Extracellular exosome	96	8.15E-12
GO-CC: 0005578	Proteinaceous extracellular matrix	24	2.17E-10
GO-CC: 0005576	Extracellular region	60	1.26E-08
GO-CC: 0005887	Integral component of plasma membrane	55	1.52E-08
GO-BP: 0030198	Extracellular matrix organization	24	1.10E-12
GO-BP: 0007155	Cell adhesion	34	1.36E-11
GO-BP: 0016337	Single organismal cell-cell adhesion	13	2.73E-07
GO-BP: 0050900	Leukocyte migration	14	3.14E-07
GO-BP: 0001666	Response to hypoxia	16	5.41E-07
GO-MF: 0008201	Heparin binding	17	1.31E-08
GO-MF: 0005539	Glycosaminoglycan binding	7	3.44E-07
GO-MF: 0005515	Protein binding	189	1.11E-06
GO-MF: 0005178	Integrin binding	12	1.60E-06
GO-MF: 0050431	Transforming growth factor beta binding	6	4.97E-06

hsa05144	Malaria	8	1.37E-04
hsa04610	Complement and coagulation cascades	8	1.16E-03
hsa04514	Cell adhesion molecules (CAMs)	11	1.91E-03
hsa04530	Tight junction	8	4.40E-03
hsa04512	ECM-receptor interaction	8	4.40E-03
GO – Gene Ontology; KEGG – Kyoto Encyclopedia of Genes and Genomes; DEGs – differentially expressed genes; BP – biological processes; CC – cell component; MF – molecular function; ECM – extracellular matrix.