16 July 2020: Database Analysis
Estimation of Hub Genes and Infiltrating Immune Cells in Non-Smoking Females with Lung Adenocarcinoma by Integrated Bioinformatic Analysis
Jie Li 1ABCDEF , Ben Wang 2BCDF , Xin Li 3BF , Yuxi Zhu 1AE*DOI: 10.12659/MSM.922680
Med Sci Monit 2020; 26:e922680
Table 2 Functional roles of 10 hub genes with prognostic significance.
| No. | Gene symbol | Regulation | Degree | Full name | Function |
|---|---|---|---|---|---|
| 1 | SPP1 | Up | 21 | Secreted Phosphoprotein 1 | SPP1 participates in a range of biological functions, including cell proliferation, adhesion, invasion, migration, and tumor angiogenesis |
| 2 | ENG | Down | 18 | Endoglin | ENG activated the TGF-β/ALK1 signaling pathway and promoted endothelial cell proliferation and migration in cancers |
| 3 | CAV1 | Down | 18 | Caveolin 1 | CAV1 transforms suppressor activity abnormal expressed in T cell leukemia in lung carcinoma and in breast carcinoma |
| 4 | ATF3 | Down | 17 | Activating Transcription Factor 3 | Over-expression of ATF3 upregulated p53 and inhibited the tumorigenesis of lung cancer |
| 5 | TOP2A | Up | 17 | DNA Topoisomerase II Alpha | TOP2A is involved in the process of chromosome condensation, chromatid separation, DNA transcription and replication. It is the target of several anti-cancer drugs |
| 6 | COL1A1 | Up | 16 | Collagen Type I Alpha 1 | COL1A1 encodes the pro-alpha1 chains of type I collagen. It is related to hypoxia and is significantly overexpressed in non-small cell lung cancer |
| 7 | CAT | Down | 15 | Catalase | CAT serves to protect cells from the toxic effects of hydrogen peroxide, and it changes the migration and invasion ability of lung cancer cell |
| 8 | TGFBR2 | Down | 15 | Transforming Growth Factor Beta Receptor 2 | TGFBR2 often alters during adenoma-carcinoma progression of some cancers |
| 9 | ANGPT1 | Down | 14 | Angiopoietin 1 | ANGPT1, a member of the angiopoietin family, plays an important role in vascular development and angiogenesis |
| 10 | PAICS | Up | 11 | Phosphoribosyl Aminoimidazole Carboxylase | PAICS is identified as an oncogene of various tumor types |