04 July 2020: Clinical Research
Implementation of Thromboelastometry for Coagulation Management in Isolated Traumatic Brain Injury Patients Undergoing Craniotomy
Marius Rimaitis 1ABCDEFG* , Diana Bilskienė 1ABE , Tomas Tamošuitis 2BE , Rimantas Vilcinis 2BDE , Kęstutis Rimaitis 1DE , Andrius Macas 1ADEGDOI: 10.12659/MSM.922879
Med Sci Monit 2020; 26:e922879
Table 5 Summarized hematologic parameters of the case group patients.
| Hematologic parameter | Case-N (n=35) | Case-CP (n=34) | |||||
|---|---|---|---|---|---|---|---|
| Preoperative | Postoperative | P | Preoperative | Postoperative | P | ||
| Hemoglobin, g/L | 140 (133–147) | 104 (95–110) | 133.5 (120.75–143.75) | 98 (89–110.5) | |||
| Hematocrit, % | 41 (38.6–43) | 31 (29–33.2) | 38.55 (35.15–41.63) | 29.4 (26.83–33.3) | |||
| SCT: | PLT, 10/L | 233 (184–269) | 168 (152–194) | 167 (108.5–223.25) | 121 (82–165.25) | ||
| PTI, % | 95 (82–111) | 73 (67.5–84) | 87 (66–109) | 72 (62.5–82.5) | |||
| INR | 1.02 (0.96–1.1) | 1.14 (1.08–1.2) | 1.06 (0.97–1.2) | 1.16 (1.09–1.24) | |||
| APTT, s | 30 (27.9–33) | 33.3 (30.65–35.55) | 32.15 (30.1–37.18) | 35 (31.25–37.2) | 0.143 | ||
| FIB, g/L | 3.74 (2.88–4.18) | 3.38 (2.77–4.03) | 2.59 (1.96–3.78) | 2.86 (2.15–3.37) | 0.614 | ||
| SCT abnormal, n (%) | 0 (0) | 15 (45.5) | 25 (73.5) | 24 (72.7) | 0.944 | ||
| ROTEM: | INTEM – CT, s | 167 (149–178) | 157.5 (147–161.75) | 0.153 | 175.5 (153.25–199.25) | 165.5 (153.75–176.75) | |
| CFT, s | 76 (64–84) | 70.5 (62.25–82.5) | 0.069 | 109 (85.75–147.5) | 92.5 (80–123.75) | ||
| A10, mm | 55 (52.75–57.5) | 55 (53–57.25) | 0.241 | 45.5 (39.75–51.25) | 48.5 (41.25–52) | 0.175 | |
| MCF, mm | 63 (61–65) | 63 (60.75–64.25) | 0.437 | 54 (51–60.5) | 57 (52–61) | 0.202 | |
| ML, % | 5 (3–8) | 6.5 (4.75–9.25) | 4 (1.75–6) | 4 (2.25–7) | |||
| ROTEM: | EXTEM – CT, s | 62 (55–66) | 59.5 (53.5–64.75) | 0.439 | 74 (64.75–88.25) | 60 (53.25–68) | |
| CFT, s | 79 (66–91) | 77.5 (59.75–87.25) | 0.042 | 122.5 (91.75–150.75) | 95 (72.25–123) | ||
| A10, mm | 56 (53.75–58.25) | 56.5 (53.75–59.25) | 0.323 | 45 (40.75–50.25) | 48 (45–55.5) | ||
| MCF, mm | 64 (62–66.25) | 64 (61–66.25) | 0.837 | 55 (50–57.5) | 57.5 (55.25–63) | ||
| ML, % | 5.5 (2–8) | 6 (4–9) | 5 (3–6) | 4 (2–6.75) | 0.806 | ||
| ROTEM: | FIBTEM – | ||||||
| A10, mm | 19 (16–21.25) | 17.5 (14–22.5) | 0.829 | 14 (8–20) | 15.5 (12–20.75) | ||
| MCF, mm | 21.5 (17–24.5) | 19.5 (15–23.5) | 0.410 | 16.5 (9–22.5) | 17.5 (13–22) | 0.197 | |
| ML, % | 1 (0–5) | 1 (0–2.25) | 0.118 | 1.5 (0–8) | 0 (0–2) | ||
| ROTEM abnormal, n (%) | 0 (0) | 2 (5.9) | 0.144 | 25 (73.5) | 15 (46.9) | ||
| Hyperfibrinolysis, n (%) | 0 (0) | 2 (5.9) | 0.144 | 9 (26.5) | 2 (6.3) | ||
| Continuous variables are reported as median (interquartile range). Categorical variables are reported in terms of frequency (percentage). N – normal; CP – coagulopathic; SCT – standard coagulation tests; PLT – platelet count; PTI – prothrombin time index; INR – international normalized ratio; APTT – partial thromboplastin time; FIB – fibrinogen. INTEM – internal coagulation pathway thromboelastometry; EXTEM – external coagulation pathway thromboelastometry; FIBTEM – fibrinogen polymerization thromboelastometry; CT – clotting time; CFT – clot formation time; A10 – clot amplitude 10 min. after CT; MCF – maximum clot firmness; ML – maximum lysis. | |||||||