Association of Serum Thyroid Hormones with the Risk and Severity of Chronic Kidney Disease Among 3563 Chinese Adults

22 June 2020 : Clinical Research

Jialin Li^1CE, Xi’ai Wu^2BD, Minjing Luo^1BF, Meihua Yan^3BD, Qian Wang^1D, Ping Li^3AG, Wenquan Niu^3CE*

DOI: 10.12659/MSM.922910

Med Sci Monit 2020; 26:e922910

Table 2 Risk prediction of thyroid hormones for chronic kidney disease (CKD) at different stages.

Significant risk factors	CKD Stage 1–2	CKD Stage 3	CKD Stage 4	CKD Stage 5

FT3 (+0.2 pg/mL)	0.65, 0.60 to 0.73,	0.60, 0.53 to 0.65,	0.61, 0.57 to 0.67,	0.99, 0.98 to 1.00, 0.088
FT4 (+0.3 ng/dL)	0.65, 0.60 to 0.73,	0.86, 0.69 to 1.07, 0.169	0.83, 0.71 to 0.98, 0.026	0.80, 0.71 to 0.91, 0.001
TSH (+0.5 μIU/mL)	0.99, 0.93 to 1.06, 0.838	1.03, 0.98 to 1.08, 0.285	1.08, 1.03 to 1.14, 0.002	1.09, 1.03 to 1.15, 0.001

FT3 (+0.2 pg/mL)	0.65, 0.58 to 0.72,	0.62, 0.56 to 0.69,	0.63, 0.58 to 0.69,	0.98, 0.97 to 0.99, 0.005
FT4 (+0.3 ng/dL)	0.76, 0.59 to 0.98, 0.034	0.84, 0.66 to 1.07, 0.151	0.83, 0.70 to 0.97, 0.022	0.79, 0.69 to 0.89,
TSH (+0.5 μIU/mL)	0.99, 0.92 to 1.06, 0.694	1.02, 0.97 to 1.08, 0.339	1.08, 1.02 to 1.14, 0.005	1.08, 1.02 to 1.14, 0.003
FT3 – free triiodothyronine; FT4 – free thyroxine; TSH – thyroid-stimulating hormone. Data are expressed as odds ratio, 95% confidence interval, P value.