22 June 2020 : Clinical Research
Association of Serum Thyroid Hormones with the Risk and Severity of Chronic Kidney Disease Among 3563 Chinese Adults
Jialin Li1CE, Xi’ai Wu2BD, Minjing Luo1BF, Meihua Yan3BD, Qian Wang1D, Ping Li3AG, Wenquan Niu3CE*DOI: 10.12659/MSM.922910
Med Sci Monit 2020; 26:e922910
Table 4 Interaction between free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) in prediction of chronic kidney disease (CKD) at different stages.
| Interaction items | OR, 95% CI, P | ||||
|---|---|---|---|---|---|
| CKD Stage 1–2 | CKD Stage 3 | CKD Stage 4 | CKD Stage 5 | ||
| FT3–FT4 | High FT3– High FT4 | Ref. | Ref. | Ref. | Ref. |
| High FT3– Low FT4 | 2.12, 1.14 to 3.94, 0.018 | 1.13, 0.51 to 2.49, 0.768 | 1.58, 0.87 to 2.86, 0.133 | 1.81, 1.30 to 2.55, | |
| Low FT3– High FT4 | 5.33, 1.58 to 18.03, 0.007 | 2.01, 0.56 to 7.22, 0.283 | 4.10, 1.26 to 13.3, 0.019 | 17.72, 7.18 to 43.74, | |
| Low FT3–Low FT4 | 11.93, 4.34 to 32.83, | 3.63, 1.14 to 9.93, 0.012 | 10.7, 4.37 to 26.23, | 22.28, 9.68 to 51.30, | |
| FT3–TSH | High FT3–Low TSH | Ref. | Ref. | Ref. | Ref. |
| High FT3–High TSH | 0.99, 0.50 to 1.97, 0.986 | 1.25, 0.59 to 2.66, 0.549 | 1.74, 1.06 to 2.85, 0.028 | 0.94, 0.52 to 1.72, 0.842 | |
| Low FT3–Low TSH | 7.68, 1.63 to 36.16, 0.010 | 12.17, 1.17 to 126.08, 0.036 | 4.30, 0.78 to 23.64, 0.094 | 15.93, 6.12 to 41.49, | |
| Low FT3–High TSH | 2.19, 0.33 to 14.49, 0.415 | 9.20, 1.12 to 75.61, 0.039 | 9.13, 1.63 to 51.25, 0.012 | 19.92, 5.88 to 67.53, | |
| FT4–TSH | High FT4–Low TSH | Ref. | Ref. | Ref. | Ref. |
| High FT4–High TSH | 0.96, 0.43 to 2.17, 0.922 | 1.36, 0.57 to 3.23, 0.478 | 2.24, 1.24 to 4.05, 0.008 | 1.77, 1.08 to 2.90, 0.022 | |
| Low FT4–Low TSH | 2.39, 0.80 to 7.13, 0.117 | 5.58, 1.62 to 19.09, 0.006 | 2.68, 1.22 to 5.93, 0.015 | 3.59, 1.91 to 6.75, | |
| Low FT4–High TSH | 1.54, 0.51 to 4.60, 0.437 | 5.51, 1.56 to 19.44, 0.008 | 3.24, 1.52 to 6.91, 0.002 | 4.36, 2.38 to 7.96, | |
| OR – odds ratio; 95% CI – 95% confidence interval; Ref. – reference group. FT3, FT4, and TSH were binarized according to the median values (FT3: 2.18 pg/mL, FT4: 1.13 ng/dL, TSH: 2.06 μIU/mL) in all study participants, and classified into high and low groups, respectively. | |||||