18 August 2020 : Clinical Research
Risk Factors for Acquisition of Carbapenem-Resistant Klebsiella pneumoniae and Mortality Among Abdominal Solid Organ Transplant Recipients with K. pneumoniae Infections
Di Wu1BCDE, Chunmei Chen2CEF, Taohua Liu3DE, Qiquan Wan1ACDEFG*DOI: 10.12659/MSM.922996
Med Sci Monit 2020; 26:e922996
Table 1 Clinical characteristic and demographic, laboratory of 68 K. pneumoniae infections recipients.
Characteristics | Value |
---|---|
Age, mean years ±SD | 44.4±10.4 |
Sex, no. of male (%) | 43 (63.2) |
Median body temperature of °C at the onset (IQR) | 37.3 (36.8~38.1) |
Temperature of 39°C or greater, n (%) | 4 (5.9) |
Nosocomial origin, n (%) | 41 (60.3) |
Inappropriate empirical antimicrobial use, n (%) | 37 (54.4) |
Carbapenem-resistant , n (%) | 38 (55.9) |
Duration of ICU stays after surgery (IQR) | 6 (5~8) |
Intraoperative blooding, ml (IQR) | 200 (100~900) |
RBC transfusion during the perioperative period, unit (IQR) | 2 (0~16.38) |
Dialysis within 1 month after transplantation, n (%) | 14 (20.6) |
Creatinine >1.5 mg/dL within 1 week after transplantation, n (%) | 36 (52.9) |
Mechanical ventilation, n (%) | 13 (19.1) |
Septic shock, n (%) | 7 (10.3) |
Acute rejection within 3 months before infection, n (%) | 2 (2.9) |
Other infections within 3 months before infection, n (%) | 9 (13.2) |
Re-operation, n (%) | 8 (11.8) |
Induction therapy, n (%) | |
Basiliximab | 18 (26.5) |
Antithymocyte globulin | 35 (51.5) |
Use of wide-spectrum antibiotics for 5 days or more within 1 month before infection, n (%) | 30 (44.1) |
Use of meropenem for 3 days or more within 1 month before infection, n (%) | 30 (44.1) |
Multiple infected organisms or sites, n (%) | 28 (41.2) |
Organ resource, no. of cases (%) | |
DCD | 66 (97.1) |
Living-related | 2 (2.9) |
Type of infections, no. of cases (%) | |
Bacteremia | 24 (35.3) |
Pulmonary infection | 13 (19.1) |
Urinary tract infection | 12 (17.6) |
Deep wound and Skin infection | 11 (16.2) |
Abdominal cavity infection | 8 (11.8) |
Patient immunosuppressant treatment, no. of cases (%) | |
Cyclosporine A | 8 (11.8) |
Tacrolimus | 57 (83.8) |
No use of calcineurin inhibitor | 3 (4.4) |
Type of transplantation, no. of cases (%) | |
Kidney | 50 (73.5) |
Liver | 18 (26.5) |
Laboratory variables from blood, no. of cases (%) | |
Lymphocyte count <300/mm | 25 (36.8) |
Albumin <30 g/L | 9 (13.2) |
WBC count >15,000/mm | 15 (22.1) |
Platelet count <50,000/mm | 11 (16.2) |
Creatinine >1.5 mg/dL | 38 (55.9) |
Time of infection onset, no. of cases (%) | |
<2 months posttransplant | 46 (67.6) |
≥2 months posttransplant | 22 (32.4) |
Mortality, no. of cases (%) | 20 (29.4) |
SD – standard deviation; ASOT – abdominal solid organ transplant; RBC – red blood cells; WBC – white blood cells; IQR – interquartile range; ICU – Intensive Care Unit; DCD – donation after cardiac death. |