18 August 2020 : Clinical Research
Risk Factors for Acquisition of Carbapenem-Resistant Klebsiella pneumoniae and Mortality Among Abdominal Solid Organ Transplant Recipients with K. pneumoniae Infections
Di Wu1BCDE, Chunmei Chen2CEF, Taohua Liu3DE, Qiquan Wan1ACDEFG*DOI: 10.12659/MSM.922996
Med Sci Monit 2020; 26:e922996
Table 1 Clinical characteristic and demographic, laboratory of 68 K. pneumoniae infections recipients.
| Characteristics | Value |
|---|---|
| Age, mean years ±SD | 44.4±10.4 |
| Sex, no. of male (%) | 43 (63.2) |
| Median body temperature of °C at the onset (IQR) | 37.3 (36.8~38.1) |
| Temperature of 39°C or greater, n (%) | 4 (5.9) |
| Nosocomial origin, n (%) | 41 (60.3) |
| Inappropriate empirical antimicrobial use, n (%) | 37 (54.4) |
| Carbapenem-resistant , n (%) | 38 (55.9) |
| Duration of ICU stays after surgery (IQR) | 6 (5~8) |
| Intraoperative blooding, ml (IQR) | 200 (100~900) |
| RBC transfusion during the perioperative period, unit (IQR) | 2 (0~16.38) |
| Dialysis within 1 month after transplantation, n (%) | 14 (20.6) |
| Creatinine >1.5 mg/dL within 1 week after transplantation, n (%) | 36 (52.9) |
| Mechanical ventilation, n (%) | 13 (19.1) |
| Septic shock, n (%) | 7 (10.3) |
| Acute rejection within 3 months before infection, n (%) | 2 (2.9) |
| Other infections within 3 months before infection, n (%) | 9 (13.2) |
| Re-operation, n (%) | 8 (11.8) |
| Induction therapy, n (%) | |
| Basiliximab | 18 (26.5) |
| Antithymocyte globulin | 35 (51.5) |
| Use of wide-spectrum antibiotics for 5 days or more within 1 month before infection, n (%) | 30 (44.1) |
| Use of meropenem for 3 days or more within 1 month before infection, n (%) | 30 (44.1) |
| Multiple infected organisms or sites, n (%) | 28 (41.2) |
| Organ resource, no. of cases (%) | |
| DCD | 66 (97.1) |
| Living-related | 2 (2.9) |
| Type of infections, no. of cases (%) | |
| Bacteremia | 24 (35.3) |
| Pulmonary infection | 13 (19.1) |
| Urinary tract infection | 12 (17.6) |
| Deep wound and Skin infection | 11 (16.2) |
| Abdominal cavity infection | 8 (11.8) |
| Patient immunosuppressant treatment, no. of cases (%) | |
| Cyclosporine A | 8 (11.8) |
| Tacrolimus | 57 (83.8) |
| No use of calcineurin inhibitor | 3 (4.4) |
| Type of transplantation, no. of cases (%) | |
| Kidney | 50 (73.5) |
| Liver | 18 (26.5) |
| Laboratory variables from blood, no. of cases (%) | |
| Lymphocyte count <300/mm | 25 (36.8) |
| Albumin <30 g/L | 9 (13.2) |
| WBC count >15,000/mm | 15 (22.1) |
| Platelet count <50,000/mm | 11 (16.2) |
| Creatinine >1.5 mg/dL | 38 (55.9) |
| Time of infection onset, no. of cases (%) | |
| <2 months posttransplant | 46 (67.6) |
| ≥2 months posttransplant | 22 (32.4) |
| Mortality, no. of cases (%) | 20 (29.4) |
| SD – standard deviation; ASOT – abdominal solid organ transplant; RBC – red blood cells; WBC – white blood cells; IQR – interquartile range; ICU – Intensive Care Unit; DCD – donation after cardiac death. | |