18 August 2020 : Clinical Research
Risk Factors for Acquisition of Carbapenem-Resistant Klebsiella pneumoniae and Mortality Among Abdominal Solid Organ Transplant Recipients with K. pneumoniae Infections
Di Wu1BCDE, Chunmei Chen2CEF, Taohua Liu3DE, Qiquan Wan1ACDEFG*DOI: 10.12659/MSM.922996
Med Sci Monit 2020; 26:e922996
Table 2 Univariate and multivariate analysis of risk factors related to crude mortality in K. pneumoniae infection recipients.
Characteristics | Mortality | Survival | P | OR (95% CI) |
---|---|---|---|---|
Total, n (%) | 20 (29.4) | 48 (70.6) | ||
Age ≥40 years | 13 (65) | 32 (66.7) | 0.895 | |
Male sex | 10 (50) | 33 (68.8) | 0.144 | |
Temperature ≥39°C | 2 (10) | 2 (4.2) | 0.714 | |
Inappropriate empirical antibiotics | 16 (80) | 21 (43.8) | 0.006* | |
Nosocomial infection | 17 (85) | 24 (50) | 0.007* | |
Liver transplantation | 6 (30) | 12 (25) | 0.670 | |
bacteremia | 13 (65) | 11 (22.9) | 0.001* | |
Early-onset infection | 15 (75) | 31 (64.6) | 0.581 | |
Re-operation | 4 (20) | 4 (8.3) | 0.343 | |
Multiple infected organisms or sites | 17 (85) | 11 (22.9) | <0.001* | |
Mechanical ventilation | 7 (35) | 6 (12.5) | 0.070 | |
The use of antithymocyte globulin | 8 (40) | 27 (56.3) | 0.222 | |
The use of tacrolimus | 15 (75) | 42 (87.5) | 0.361 | |
Septic shock | 6 (30) | 1 (2.1) | 0.003* | |
Platelet count <50,000/mm | 6 (30) | 5 (10.4) | 0.102 | |
Lymphocyte count <300/mm | 10 (50) | 15 (31.3) | 0.144 | |
Albumin <30 g/L | 5 (25) | 4 (8.3) | 0.146 | |
WBC count >15,000/mm | 7 (35) | 8 (16.7) | 0.180 | |
Creatinine >1.5 mg/dL | 12 (60) | 26 (54.2) | 0.659 | |
Carbapenem-resistant | 13 (65) | 25 (52.1) | 0.328 | |
Multiple infected organisms or sites | 0.001* | 22.034 (4.348–111.653) | ||
Septic shock | 0.016* | 27.090 (1.841–398.512) | ||
-value from Pearson’s χ test or Fisher’s exact test in univariate analysis and from multiple logistic regression in multivariate analysis. * The -values are statistically significant. OR – odds ratio; CI – confidence interval; WBC – white blood cells. |