11 July 2020: Database Analysis
Clinicopathological Characteristics and Survival Outcomes of Primary Hepatic Neuroendocrine Tumor: A Surveillance, Epidemiology, and End Results (SEER) Population-Based Study
Yu-feng Li 12ABCE , Qiu-qiang Zhang 12BF , Wei-lin Wang 1234AEG*DOI: 10.12659/MSM.923375
Med Sci Monit 2020; 26:e923375
Table 2 Multivariate Cox proportional hazards regression analysis for overall survival (OS) and disease-specific survival (DSS).
| Characteristics | OS | DSS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Sex | ||||||
| Female | Reference | Reference | ||||
| Male | 1.326 | 0.986–1.783 | 0.062 | 1.270 | 0.925–1.744 | 0.140 |
| Age at diagnosis (years) | ||||||
| >65 | Reference | Reference | ||||
| ≤65 | 0.567 | 0.425–0.757 | 0.651 | 0.477–0.887 | ||
| Race | ||||||
| White | Reference | Reference | ||||
| Black | 1.137 | 0.753–1.717 | 0.542 | 1.075 | 0.683–1.692 | 0.754 |
| Others | 1.284 | 0.775–2.127 | 0.331 | 1.307 | 0.761–2.243 | 0.331 |
| Marital status | ||||||
| Married | Reference | Reference | ||||
| Unmarried | 1.534 | 1.131–2.081 | 1.617 | 1.165–2.244 | ||
| Unknown | 1.195 | 0.668–2.136 | 0.548 | 1.144 | 0.603–2.171 | 0.681 |
| Histological grade | ||||||
| I+II | Reference | Reference | ||||
| III+IV | 3.068 | 1.973–4.771 | 3.421 | 2.149–5.446 | ||
| Unknown | 1.192 | 0.801–1.773 | 0.386 | 1.778 | 0.750–1.778 | 0.512 |
| SEER stage | ||||||
| Localized | Reference | Reference | ||||
| Regional | 1.225 | 0.817–1.837 | 0.325 | 1.262 | 0.815–1.955 | 0.297 |
| Distant | 1.055 | 0.696–1.600 | 0.800 | 1.122 | 0.717–1.756 | 0.615 |
| Unknown | 1.160 | 0.787–1.712 | 0.454 | 1.147 | 0.746–1.763 | 0.533 |
| Tumor-directed surgery | ||||||
| Yes | Reference | Reference | ||||
| No | 3.636 | 2.369–5.580 | 3.875 | 2.420–6.205 | ||