05 September 2020: Database Analysis
Identification of Hub Genes Associated with Hypertension and Their Interaction with miRNA Based on Weighted Gene Coexpression Network Analysis (WGCNA) Analysis
Zongjin Li 1ABCDEF , Jacqueline Chyr 2EF , Zeyu Jia 3BF , Lina Wang 4EF , Xi Hu 4DF , Xiaoming Wu 4AC* , Changxin Song 5DG*DOI: 10.12659/MSM.923514
Med Sci Monit 2020; 26:e923514
Supplementary Table 3 The results of salmon module analysis in mirPath.
| KEGG pathway | p-value | #genes | #miRNAs |
|---|---|---|---|
| Hippo signaling pathway | 2.18E-07 | 94 | 28 |
| Adherens junction | 3.19E-07 | 55 | 26 |
| Proteoglycans in cancer | 3.19E-07 | 123 | 29 |
| Pathways in cancer | 1.90E-06 | 229 | 33 |
| Prostate cancer | 3.25E-06 | 64 | 27 |
| TGF-beta signaling pathway | 4.56E-06 | 51 | 26 |
| Pancreatic cancer | 1.62E-05 | 48 | 24 |
| Transcriptional misregulation in cancer | 1.62E-05 | 105 | 29 |
| Protein processing in endoplasmic reticulum | 2.64E-05 | 106 | 27 |
| Chronic myeloid leukemia | 3.12E-05 | 50 | 26 |
| FoxO signaling pathway | 8.58E-05 | 83 | 29 |
| Cell cycle | 9.30E-05 | 76 | 28 |
| Ubiquitin mediated proteolysis | 0.000137428 | 89 | 28 |
| ErbB signaling pathway | 0.000220758 | 56 | 23 |
| AMPK signaling pathway | 0.000220758 | 77 | 28 |
| Hepatitis B | 0.000220758 | 81 | 28 |
| Prion diseases | 0.000234754 | 14 | 12 |
| Renal cell carcinoma | 0.000234754 | 45 | 24 |
| Fatty acid biosynthesis | 0.000328055 | 8 | 11 |
| Wnt signaling pathway | 0.000328055 | 84 | 26 |
| Endocytosis | 0.000328055 | 120 | 31 |
| Colorectal cancer | 0.000538812 | 43 | 24 |
| Focal adhesion | 0.00055548 | 122 | 27 |
| Thyroid hormone signaling pathway | 0.000591287 | 71 | 25 |
| Neurotrophin signaling pathway | 0.000591287 | 72 | 27 |
| Bacterial invasion of epithelial cells | 0.000592348 | 48 | 24 |
| Shigellosis | 0.001159846 | 42 | 25 |
| SNARE interactions in vesicular transport | 0.001507172 | 22 | 14 |
| Acute myeloid leukemia | 0.001507172 | 37 | 22 |
| Non-small cell lung cancer | 0.001507172 | 35 | 22 |
| Viral carcinogenesis | 0.001664854 | 104 | 31 |
| Glycosaminoglycan biosynthesis – chondroitin sulfate/dermatan sulfate | 0.001674489 | 11 | 11 |
| Glioma | 0.00182823 | 40 | 23 |
| Axon guidance | 0.00228799 | 73 | 27 |
| Adipocytokine signaling pathway | 0.002582229 | 46 | 20 |
| mRNA surveillance pathway | 0.002582229 | 56 | 24 |
| Choline metabolism in cancer | 0.003052312 | 63 | 26 |
| Endometrial cancer | 0.00337732 | 34 | 24 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 0.004005275 | 38 | 21 |
| Small cell lung cancer | 0.00695403 | 53 | 22 |
| p53 signaling pathway | 0.00695403 | 42 | 26 |
| Melanoma | 0.010615755 | 42 | 26 |
| PI3K-Akt signaling pathway | 0.010615755 | 182 | 29 |
| Alanine, aspartate and glutamate metabolism | 0.013556846 | 23 | 18 |
| Sphingolipid signaling pathway | 0.013556846 | 67 | 25 |
| Signaling pathways regulating pluripotency of stem cells | 0.019376413 | 78 | 29 |
| Insulin signaling pathway | 0.020843228 | 80 | 24 |
| Rap1 signaling pathway | 0.022783789 | 113 | 28 |
| Fc gamma R-mediated phagocytosis | 0.032659471 | 53 | 20 |
| MAPK signaling pathway | 0.034939635 | 133 | 31 |
| RNA degradation | 0.039468488 | 49 | 20 |
| RNA transport | 0.039695937 | 94 | 28 |
| HIF-1 signaling pathway | 0.045306902 | 60 | 27 |