05 September 2020 : Database Analysis
Identification of Hub Genes Associated with Hypertension and Their Interaction with miRNA Based on Weighted Gene Coexpression Network Analysis (WGCNA) Analysis
Zongjin Li1ABCDEF, Jacqueline Chyr2EF, Zeyu Jia3BF, Lina Wang4EF, Xi Hu4DF, Xiaoming Wu4AC, Changxin Song5DG*DOI: 10.12659/MSM.923514
Med Sci Monit 2020; 26:e923514
Supplementary Table 3 The results of salmon module analysis in mirPath.
| KEGG pathway | p-value | #genes | #miRNAs |
|---|---|---|---|
| Hippo signaling pathway | 2.18E-07 | 94 | 28 |
| Adherens junction | 3.19E-07 | 55 | 26 |
| Proteoglycans in cancer | 3.19E-07 | 123 | 29 |
| Pathways in cancer | 1.90E-06 | 229 | 33 |
| Prostate cancer | 3.25E-06 | 64 | 27 |
| TGF-beta signaling pathway | 4.56E-06 | 51 | 26 |
| Pancreatic cancer | 1.62E-05 | 48 | 24 |
| Transcriptional misregulation in cancer | 1.62E-05 | 105 | 29 |
| Protein processing in endoplasmic reticulum | 2.64E-05 | 106 | 27 |
| Chronic myeloid leukemia | 3.12E-05 | 50 | 26 |
| FoxO signaling pathway | 8.58E-05 | 83 | 29 |
| Cell cycle | 9.30E-05 | 76 | 28 |
| Ubiquitin mediated proteolysis | 0.000137428 | 89 | 28 |
| ErbB signaling pathway | 0.000220758 | 56 | 23 |
| AMPK signaling pathway | 0.000220758 | 77 | 28 |
| Hepatitis B | 0.000220758 | 81 | 28 |
| Prion diseases | 0.000234754 | 14 | 12 |
| Renal cell carcinoma | 0.000234754 | 45 | 24 |
| Fatty acid biosynthesis | 0.000328055 | 8 | 11 |
| Wnt signaling pathway | 0.000328055 | 84 | 26 |
| Endocytosis | 0.000328055 | 120 | 31 |
| Colorectal cancer | 0.000538812 | 43 | 24 |
| Focal adhesion | 0.00055548 | 122 | 27 |
| Thyroid hormone signaling pathway | 0.000591287 | 71 | 25 |
| Neurotrophin signaling pathway | 0.000591287 | 72 | 27 |
| Bacterial invasion of epithelial cells | 0.000592348 | 48 | 24 |
| Shigellosis | 0.001159846 | 42 | 25 |
| SNARE interactions in vesicular transport | 0.001507172 | 22 | 14 |
| Acute myeloid leukemia | 0.001507172 | 37 | 22 |
| Non-small cell lung cancer | 0.001507172 | 35 | 22 |
| Viral carcinogenesis | 0.001664854 | 104 | 31 |
| Glycosaminoglycan biosynthesis – chondroitin sulfate/dermatan sulfate | 0.001674489 | 11 | 11 |
| Glioma | 0.00182823 | 40 | 23 |
| Axon guidance | 0.00228799 | 73 | 27 |
| Adipocytokine signaling pathway | 0.002582229 | 46 | 20 |
| mRNA surveillance pathway | 0.002582229 | 56 | 24 |
| Choline metabolism in cancer | 0.003052312 | 63 | 26 |
| Endometrial cancer | 0.00337732 | 34 | 24 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 0.004005275 | 38 | 21 |
| Small cell lung cancer | 0.00695403 | 53 | 22 |
| p53 signaling pathway | 0.00695403 | 42 | 26 |
| Melanoma | 0.010615755 | 42 | 26 |
| PI3K-Akt signaling pathway | 0.010615755 | 182 | 29 |
| Alanine, aspartate and glutamate metabolism | 0.013556846 | 23 | 18 |
| Sphingolipid signaling pathway | 0.013556846 | 67 | 25 |
| Signaling pathways regulating pluripotency of stem cells | 0.019376413 | 78 | 29 |
| Insulin signaling pathway | 0.020843228 | 80 | 24 |
| Rap1 signaling pathway | 0.022783789 | 113 | 28 |
| Fc gamma R-mediated phagocytosis | 0.032659471 | 53 | 20 |
| MAPK signaling pathway | 0.034939635 | 133 | 31 |
| RNA degradation | 0.039468488 | 49 | 20 |
| RNA transport | 0.039695937 | 94 | 28 |
| HIF-1 signaling pathway | 0.045306902 | 60 | 27 |