Fibrinogen-Like Protein 2 (FGL2) is a Novel Biomarker for Clinical Prediction of Human Breast Cancer

Yanyan Feng; Chunguang Guo; Hesong Wang; Lu Zhao; Wei Wang; Ting Wang; Yuyin Feng; Kai Yuan; Guangrui Huang

doi:10.12659/MSM.923531

27 July 2020: Database Analysis

Fibrinogen-Like Protein 2 (FGL2) is a Novel Biomarker for Clinical Prediction of Human Breast Cancer

Yanyan Feng ^1AC* , Chunguang Guo ^2BC* , Hesong Wang ^1B , Lu Zhao ^1CF , Wei Wang ^1C , Ting Wang ^1BC , Yuyin Feng ^3C , Kai Yuan ^1BCDF* , Guangrui Huang ^3AEG*

DOI: 10.12659/MSM.923531

Med Sci Monit 2020; 26:e923531

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Table 1 Association of FGL2 with the clinical pathological characteristics of breast cancer patients derived from the TCGA database.

Variables	Clinical pathological	Number	Mean±SD	P
Sex	Female	1091	2.89±1.06	0.004
Sex	Male	12	2.00±0.89	0.004
Radiation therapy	No	439	2.77±1.05	0.004
Radiation therapy	Yes	553	2.96±1.05	0.004
Age		589	2.89±1.07	0.713
Age	≥60	513	2.86±1.04	0.713
HER2 status	Negative	290	2.92±1.01	0.496
HER2 status	Positive	69	2.83±0.95	0.496
ER status	Negative	212	2.87±1.18	0.458
ER status	Positive	727	2.93±1.01	0.458
PR status	Negative	308	2.79±1.13	0.013
PR status	Positive	628	2.98±1.00	0.013
T stage	T1	281	3.02±1.04	0.038
	T2	641	2.83±1.07
	T3	138	2.93±1.06
	T4	40	2.58±0.94
N stage	N0	519	2.88±1.11	0.28
	N1	366	2.85±1.01
	N2	120	2.95±1.03
	N3	78	3.07±0.94
M stage	M0	917	2.87±1.06	0.134
M stage	M1	22	2.53±0.93	0.134
TNM stage	I	182	3.00±1.08	0.055
	II	628	2.83±1.84
	III	250	2.95±1.00
	IV	20	2.45±0.95

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Fibrinogen-Like Protein 2 (FGL2) is a Novel Biomarker for Clinical Prediction of Human Breast Cancer

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