27 July 2020: Database Analysis
Fibrinogen-Like Protein 2 (FGL2) is a Novel Biomarker for Clinical Prediction of Human Breast Cancer
Yanyan Feng 1AC* , Chunguang Guo 2BC* , Hesong Wang 1B , Lu Zhao 1CF , Wei Wang 1C , Ting Wang 1BC , Yuyin Feng 3C , Kai Yuan 1BCDF* , Guangrui Huang 3AEG*DOI: 10.12659/MSM.923531
Med Sci Monit 2020; 26:e923531
Supplementary Table 1 FGL2 was positively correlated with most immune marker sets in the TIMER database.
| Description | Gene markers | Cor | P | Description | Gene markers | Cor | P |
|---|---|---|---|---|---|---|---|
| T cell (general) | CD3D | 0.589 | 6.66E-94 | CTL (cytotoxic T lymphocytes) | CD8A | 0.61 | 2.93E-102 |
| CD3E | 0.621 | 3.80E-107 | CD8B | 0.486 | 4.19E-60 | ||
| CD2 | 0.658 | 2.29E-124 | GZMB | 0.45 | 1.12E-50 | ||
| B cell | CD19 | 0.362 | 2.53E-32 | Dendritic cell | HLA-DPB1 | 0.65 | 2.23E-120 |
| CD79A | 0.386 | 1.37E-36 | HLA-DQB1 | 0.472 | 2.83E-56 | ||
| CD79B | 0.341 | 1.59E-28 | HLA-DRA | 0.758 | 2.83E-186 | ||
| CD22 | 0.225 | 6.93E-13 | HLA-DPA1 | 0.774 | 2.36E-199 | ||
| M1 macrophage | INOS | 0.003 | 9.33E-01 | DEC-205 | 0.411 | 9.88E-42 | |
| CIITA | 0.648 | 2.39E-119 | BDCA-1 | 0.46 | 2.96E-53 | ||
| IRF5 | 0.289 | 1.49E-20 | BDCA-4 | 0.292 | 5.93E-21 | ||
| COX2 | 0.196 | 4.34E-10 | BDCA-2 | 0.466 | 8.39E-55 | ||
| M2 macrophage | CD163 | 0.568 | 6.67E-86 | CD11c | 0.547 | 1.03E-78 | |
| IRF4 | 0.591 | 1.22E-94 | Th1 | CD38 | 0.555 | 2.26E-81 | |
| VSIG4 | 0.476 | 2.84E-57 | T-bet | 0.597 | 3.80E-97 | ||
| MS4A4A | 0.655 | 9.05E-123 | STAT4 | 0.612 | 4.38E-103 | ||
| TAM | CCL2 | 0.431 | 2.84E-46 | STAT1 | 0.483 | 3.35E-59 | |
| CCL5 | 0.529 | 1.02E-72 | IFN-γ | 0.519 | 1.19E-69 | ||
| CD68 | 0.562 | 9.57E-84 | TNF-α | 0.224 | 9.45E-13 | ||
| IL10 | 0.551 | 5.84E-80 | Th2 | GATA3 | −0.107 | 7.48E-04 | |
| Neutrophils | CD66b (CEACAM8) | 0.031 | 3.33E-01 | IL13 | 0.184 | 5.48E-09 | |
| CD15 | 0.327 | 2.91E-26 | STAT6 | 0.044 | 1.63E-01 | ||
| CD11b (ITGAM) | 0.517 | 6.19E-69 | Tfh | BCL6 | 0.108 | 6.77E-04 | |
| CCR7 | 0.49 | 4.27E-61 | CD200 | 0.358 | 1.79E-31 | ||
| Natural killer cell | NKp46 | 0.457 | 1.99E-52 | IL21 | 0.387 | 7.16E-37 | |
| NKp44 | 0.165 | 1.61E-07 | ICOS | 0.604 | 0.09E-100 | ||
| NKp30 | 0.473 | 1.32E-56 | Th17 | STAT3 | 0.138 | 1.19E-05 | |
| FCGR3A | 0.592 | 4.66E-95 | IL17A | 0.16 | 3.69E-07 | ||
| FCGR3B | 0.325 | 6.52E-26 | IL1A | 0.295 | 1.86E-21 | ||
| NKG2A (KLRC1) | 0.468 | 3.30E-55 | IL1B | 0.444 | 2.40E-49 | ||
| KIR2DL1 | 0.277 | 5.07E-19 | CCL20 | 0.119 | 1.73E-04 | ||
| KIR2DL3 | 0.312 | 7.11E-24 | Treg | FOXP3 | 0.493 | 4.48E-62 | |
| KIR3DL1 | 0.337 | 8.71E-28 | CCR8 | 0.562 | 6.60E-84 | ||
| TGFβ | 0.209 | 2.95E-11 |