27 July 2020: Database Analysis
Fibrinogen-Like Protein 2 (FGL2) is a Novel Biomarker for Clinical Prediction of Human Breast Cancer
Yanyan Feng 1AC* , Chunguang Guo 2BC* , Hesong Wang 1B , Lu Zhao 1CF , Wei Wang 1C , Ting Wang 1BC , Yuyin Feng 3C , Kai Yuan 1BCDF* , Guangrui Huang 3AEG*DOI: 10.12659/MSM.923531
Med Sci Monit 2020; 26:e923531
Supplementary Table 2 FGL2 was positively correlated with most immune marker sets in the GEPIA database.
| Description | Gene markers | Cor | P | Description | Gene markers | Cor | P |
|---|---|---|---|---|---|---|---|
| T cell (general) | CD3D | 0.51 | 0 | CTL (cytotoxic T lymphocytes ) | CD8A | 0.64 | 0 |
| CD3E | 0.56 | 0 | CD8B | 0.44 | 0 | ||
| CD2 | 0.66 | 0 | GZMB | 0.45 | 0 | ||
| B cell | CD19 | 0.23 | 1.40E-14 | Dendritic cell | HLA-DPB1 | 0.65 | 0 |
| CD79A | 0.28 | 0 | HLA-DQB1 | 0.39 | 0 | ||
| CD79B | 0.26 | 0 | HLA-DRA | 0.74 | 0 | ||
| CD22 | 0.19 | 2.00E-10 | HLA-DPA1 | 0.76 | 0 | ||
| M1 Macrophage | INOS | −0.021 | 4.90E-01 | DEC-205 | 0.44 | 0 | |
| CIITA | 0.54 | 0 | BDCA-1 | 0.48 | 0 | ||
| IRF5 | 0.34 | 0 | BDCA-4 | 0.39 | 0 | ||
| COX2 | −0.022 | 4.70E-01 | BDCA-2 | 0.38 | 0 | ||
| M2 Macrophage | CD163 | 0.45 | 0 | CD11c | 0.53 | 0 | |
| IRF4 | 0.44 | 0 | Th1 | CD38 | 0.55 | 0 | |
| VSIG4 | 0.46 | 0 | T-bet | 0.65 | 0 | ||
| MS4A4A | 0.64 | 0 | STAT4 | 0.64 | 0 | ||
| TAM | CCL2 | 0.35 | 0 | STAT1 | 0.5 | 0 | |
| CCL5 | 0.5 | 0 | IFN-γ | 0.47 | 0 | ||
| CD68 | 0.53 | 0 | TNF-α | 0.15 | 5.80E-07 | ||
| IL10 | 0.56 | 0 | Th2 | GATA3 | −0.16 | 2.40E-07 | |
| Neutrophils | CD66b (CEACAM8) | 0.049 | 1.10E-01 | IL13 | 0.26 | 0 | |
| CD15 | 0.41 | 0 | STAT6 | 0.24 | 1.80E-15 | ||
| CD11b (ITGAM) | 0.31 | 0 | Tfh | BCL6 | 0.18 | 3.70E-09 | |
| CCR7 | 0.2 | 2.60E-11 | CD200 | 0.43 | 0 | ||
| Natural killer cell | NKp46 | 0.59 | 0 | IL21 | 0.53 | 0 | |
| NKp44 | 0.02 | 5.10E-01 | ICOS | 0.64 | 0 | ||
| NKp30 | 0.3 | 0 | Th17 | STAT3 | 0.27 | 0 | |
| FCGR3A | 0.59 | 0 | IL17A | 0.097 | 1.40E-03 | ||
| FCGR3B | 0.078 | 1.10E-02 | IL1A | 0.039 | 2.00E-01 | ||
| NKG2A (KLRC1) | 0.35 | 0 | IL1B | 0.37 | 0 | ||
| KIR2DL1 | 0.021 | 4.90E-01 | CCL20 | 0.019 | 5.20E-01 | ||
| KIR2DL3 | 0.32 | 0 | Treg | FOXP3 | 0.54 | 0 | |
| KIR3DL1 | 0.34 | 0 | CCR8 | 0.44 | 0 | ||
| TGFβ | 0.25 | 0 |