04 August 2020: Database Analysis
Sirtuin 3 mRNA Expression is Downregulated in the Brain Tissues of Alzheimer’s Disease Patients: A Bioinformatic and Data Mining Approach
Shuang Song 12ABCDEF , Bin Li 12A , Zhen Jia 12C , Li Guo 12AG*DOI: 10.12659/MSM.923547
Med Sci Monit 2020; 26:e923547
Table 3 GEO2R analysis of microarray datasets of samples from other neurodegenerative diseases and blood samples from Alzheimer’s disease patients.
| GEO ID | Disease | Tissue | Case number | Control number | Adjusted P value | P value | t | B | Log2FC | Gene symbol |
|---|---|---|---|---|---|---|---|---|---|---|
| GSE63060 | AD | Blood | 145 | 104 | 5.29E-04 | 2.00E-05 | 4.35 | 2.12 | 9.20E-02 | SIRT7 |
| GSE63060 | AD | Blood | 145 | 104 | 6.75E-03 | 4.17E-04 | 3.58 | −0.74 | 3.24E-02 | SIRT6 |
| GSE63061 | AD | Blood | 139 | 134 | 3.91E-03 | 1.27E-04 | 3.89 | 0.09 | 6.33E-02 | SIRT2 |
| GSE63061 | AD | Blood | 139 | 134 | 4.83E-02 | 4.27E-03 | 2.88 | −3.17 | 4.44E-02 | SIRT7 |
| GSE20291 | PD | Putamen | 15 | 20 | ns | |||||
| GSE1751 | HD | Blood | 12 | 14 | 1.53E-05 | 1.67E-07 | 6.93 | 7.36 | 1.08E+00 | SIRT1 |
| GSE1751 | HD | Blood | 12 | 14 | 3.12E-02 | 3.97E-03 | −3.14 | −2.38 | -6.61E-01 | SIRT5 |
| GSE7621 | PD | Substantia nigra | 16 | 9 | ns | |||||
| Sirtuin-related RNA with an adjusted -value less than 0.05 was considered significant, and ns indicates no significant results. | ||||||||||