Expression Profile and Prognostic Values of Mini-Chromosome Maintenance Families (MCMs) in Breast Cancer

24 August 2020 : Database Analysis

Lin Cheng^1ABCDEF, Zhangmin Tan^2BCDEF, Zenan Huang^1BCDF, Yuhang Pan^3CDF, Wenhui Zhang^4CDF, Jiani Wang^1ADEG*

DOI: 10.12659/MSM.923673

Med Sci Monit 2020; 26:e923673

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Table 2 Correlation of MCMs mRNA expression with clinicopathological features for patients with breast carcinoma.

Variables	MCM2		MCM3		MCM4		MCM5		MCM6		MCM7
Variables	No.	mRNA/ p-value	No.	mRNA/ p-value	No.	mRNA/ p-value	No.	mRNA/ p-value	No.	mRNA/ p-value	No.	mRNA/ p-value
Age
≤51	1392	0.0149	1392	<0.0001	1353	0.6471	1361	0.0757	1392	0.0226	1492	<0.0001
>51	2210	↓	2210	↓	2055	–	2142	–	2209	↓	2263	↓
Nodal status
−	2493	0.4368	2493	0.0062	2380	0.0959	2447	0.4971	2493	0.7000	2447	0.1717
+	1562	–	1562	↓	1494	–	1509	–	1561	–	1761	–
ER (IHC)
−	1446	<0.0001	1559	<0.0001	1519	<0.0001	1525	<0.0001	1559	<0.0001	1583	<0.0001
+	3766	↓	3988	↓	3836	↓	3923	↓	3987	↓	4104	↓
PR (IHC)
−	804	<0.0001	946	<0.0001	936	<0.0001	946	<0.0001	946	<0.0001	1076	<0.0001
+	1249	↓	1439	↓	1390	↓	1439	↓	1439	↓	1545	↓
HER2 (IHC)
−	1409	0.0436	1409	0.1203	1357	0.0419	1409	0.2175	1409	0.1689	1596	0.2159
+	201	↑	201	–	198	↑	201	–	201	–	217	–
Triple-negative status
Not	1060	<0.0001	1144	<0.0001	1094	<0.0001	1144	<0.0001	1144	<0.0001	1144	<0.0001
TNBC	3942	↑	4200	↑	4072	↑	4200	↑	4200	↑	4200	↑
ER (IHC), PR (IHC) and HER2 (IHC) represent oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 by immunohistochemistry, respectively. TNBC represents basal-like subtype (PAM50) status and/or triple negative breast cancer status by IHC.

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