11 August 2020 : Review article
Current Status of Research on the Role of Circular RNAs in Hepatocellular Carcinoma and Clinical Implications
Ren-Chao Zou1E, Ling-Lin Li23CDE, Hong-Ling Yuan2A*DOI: 10.12659/MSM.923832
Med Sci Monit 2020; 26:e923832
Background
Overview of circRNA
Properties of circRNAs
Roles of circRNAs
Sponges of miRNA
CircRNAs-binding proteins
circRNAs Regulate Alternative Splicing, Transcription and Translation
Potential to Encode Proteins
circRNAs in Diseases
Overview of HCC
Roles of circRNAs in HCC
Tumor Inhibition
Tumor Promotion
Biomarker
Conclusions
References
Table 1 Brief summary of circRNAs as biomarkers for HCC.
| Name | Disease | Conclusion | DOI |
|---|---|---|---|
| ciRS-7 | Hepatocellular carcinoma | ciRS-7 was one of the independent factors, and may be a promising biomarker for hepatic MVI and a novel therapy target for restraining MVI | 10.1007/s00432-016-2256-7 |
| hsa_circ_0003570 | Hepatocellular carcinoma | hsa_circ_0003570 expression levels were associated with HCC clinicopathological characteristics | 10.1002/jcla.22239 |
| hsa_circ_0005075 | Hepatocellular carcinoma | hsa_circ_0005075 promotes proliferation, migration, and invasiveness of HCC via miR-431 regulation | 10.1016/j.biopha.2018.01.150 |