Chlamydial-Secreted Protease Chlamydia High Temperature Requirement Protein A (cHtrA) Degrades Human Cathelicidin LL-37 and Suppresses Its Anti-Chlamydial Activity

Xiaohua Dong; Wanxing Zhang; Jianmei Hou; Miaomiao Ma; Congzhong Zhu; Huiping Wang; Shuping Hou

doi:10.12659/MSM.923909

07 July 2020 : Laboratory Research

Chlamydial-Secreted Protease Chlamydia High Temperature Requirement Protein A (cHtrA) Degrades Human Cathelicidin LL-37 and Suppresses Its Anti-Chlamydial Activity

Xiaohua Dong^1AB, Wanxing Zhang^2CE, Jianmei Hou^3DF, Miaomiao Ma^2DF, Congzhong Zhu^4DF, Huiping Wang^2AG, Shuping Hou^2AG*

DOI: 10.12659/MSM.923909

Med Sci Monit 2020; 26:e923909

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Table 1 Anti-chlamydial activities of 5 human antimicrobial peptides (AMPs). AMPs were titrated for their ability to inhibit C. trachomatis serovar L2 growth. The minimal concentrations required for inhibiting 50% chlamydial infection (IC50) were determined for each AMP. The data are expressed as μg/mL (mean±SD) and were derived from triplicate testing with duplicates in independent experiments.

Anti-chlamydial activities of AMPs.
AMPs		IC50/ml (χ̄±S)
Cathelicidin	LL-37	4.82±0.94
α-defensins	HNP1	60.67±5.13
α-defensins	HNP3	69.87±7.45
β-defensins	HBD2	28.33±9.45
β-defensins	HBD4	47.70±6.15

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Chlamydial-Secreted Protease Chlamydia High Temperature Requirement Protein A (cHtrA) Degrades Human Cathelicidin LL-37 and Suppresses Its Anti-Chlamydial Activity

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