07 July 2020: Lab/In Vitro Research
Chlamydial-Secreted Protease Chlamydia High Temperature Requirement Protein A (cHtrA) Degrades Human Cathelicidin LL-37 and Suppresses Its Anti-Chlamydial Activity
Xiaohua Dong 1AB* , Wanxing Zhang 2CE* , Jianmei Hou 3DF , Miaomiao Ma 2DF , Congzhong Zhu 4DF , Huiping Wang 2AG , Shuping Hou 2AG*DOI: 10.12659/MSM.923909
Med Sci Monit 2020; 26:e923909
Table 1 Anti-chlamydial activities of 5 human antimicrobial peptides (AMPs). AMPs were titrated for their ability to inhibit C. trachomatis serovar L2 growth. The minimal concentrations required for inhibiting 50% chlamydial infection (IC50) were determined for each AMP. The data are expressed as μg/mL (mean±SD) and were derived from triplicate testing with duplicates in independent experiments.
| Anti-chlamydial activities of AMPs. | ||
|---|---|---|
| AMPs | IC50/ml (χ̄±S) | |
| Cathelicidin | LL-37 | 4.82±0.94 |
| α-defensins | HNP1 | 60.67±5.13 |
| HNP3 | 69.87±7.45 | |
| β-defensins | HBD2 | 28.33±9.45 |
| HBD4 | 47.70±6.15 | |