07 May 2020>: Lab/In Vitro Research
Potential Molecular Mechanisms and Drugs for Aconitine-Induced Cardiotoxicity in Zebrafish through RNA Sequencing and Bioinformatics Analysis
Mingzhu Wang 1CDEF , Yanan Shi 1BDF , Lei Yao 1CDF , Qiang Li 2ACDFG , Youhua Wang 3ABDFG , Deyu Fu 1ABEFG*DOI: 10.12659/MSM.924092
Med Sci Monit 2020; 26:e924092
Table 1 Heart rates and SV-BA of zebrafish in each group at 72 hpf (n=16).
Groups | Heart rates* (bpm) (χ̄±s) | SV-BA# (μm) (χ̄±s) |
---|---|---|
Control | 163.7±3.1 | 131.1±3.5 |
AC 15 mg/L | 199.0±4.8 | 163.8±4.9 |
−6.1 | −5.4 | |
0.000 | 0.000 | |
There was a significant difference between the control group and the AC 15 mg/L group both in heart rates and SV-BA ( t=−6.1, |