19 August 2020 : Database Analysis
Screening and Identification of Potential Peripheral Blood Biomarkers for Alzheimer’s Disease Based on Bioinformatics Analysis
Xin Wang1BCD, Lantao Wang1AEF*DOI: 10.12659/MSM.924263
Med Sci Monit 2020; 26:e924263
Table 2 Gene Set Enrichment Analysis (GSEA)-based Gene Ontology (GO) snalysis.
| Term | Size | NES | P-val | Rank at max | Leading edge |
|---|---|---|---|---|---|
| GO_OLIGOSACCHARIDE_LIPID_INTERMEDIATE_BIOSYNTHETIC_PROCESS | 19 | −1.6877409 | 0.006097561 | 2994 | tags=37%, list=17%, signal=44% |
| GO_NLS_BEARING_PROTEIN_IMPORT_INTO_NUCLEUS | 21 | −1.6966152 | 0.002008032 | 2889 | tags=48%, list=16%, signal=57% |
| GO_CYCLIN_BINDING | 18 | −1.7483643 | 0 | 3612 | tags=56%, list=21%, signal=70% |
| GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX | 30 | −1.7815279 | 0 | 4016 | tags=63%, list=23%, signal=82% |
| GO_UBIQUITIN_LIKE_PROTEIN_TRANSFERASE_ACTIVITY | 390 | −1.5787058 | 0.01764706 | 4260 | tags=41%, list=24%, signal=53% |
| GO_REGULATION_OF_CGMP_BIOSYNTHETIC_PROCESS | 21 | 1.7511773 | 0.007677543 | 4576 | tags=62%, list=26%, signal=84% |
| GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE | 22 | 1.8657521 | 0 | 3735 | tags=55%, list=21%, signal=69% |
| GO_NEUROTRANSMITTER_TRANSPORTER_ACTIVITY | 25 | 1.8388035 | 0.002 | 2593 | tags=44%, list=15%, signal=52% |
| GO_MONOAMINE_TRANSPORT | 22 | 1.7464089 | 0.012121212 | 3035 | tags=45%, list=17%, signal=55% |
| GO_NEUROTRANSMITTER_SODIUM_SYMPORTER_ACTIVITY | 19 | 1.7252073 | 0.014141414 | 2593 | tags=47%, list=15%, signal=55% |