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19 August 2020: Database Analysis

Screening and Identification of Potential Peripheral Blood Biomarkers for Alzheimer’s Disease Based on Bioinformatics Analysis

Xin Wang BCD , Lantao Wang AEF*

DOI: 10.12659/MSM.924263

Med Sci Monit 2020; 26:e924263

Table 4 Summary of hub genes.

SRCSRC proto-oncogene, non-receptor tyrosine kinaseGO: 2000386 positive regulation of ovarian follicle development;GO: 0086098 angiotensin-activated signaling pathway involved in heart process;GO: 0001545 primary ovarian follicle growth
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1GO: 0035666 TRIF-dependent toll-like receptor signaling pathway;GO: 0070423 nucleotide-binding oligomerization domain containing signaling pathway;GO: 0002756 MyD88-independent toll-like receptor signaling pathway
UBBUbiquitin BGO: 0021888 hypothalamus gonadotrophin-releasing hormone neuron development;GO: 0035666 TRIF-dependent toll-like receptor signaling pathway;GO: 0021886 hypothalamus gonadotrophin-releasing hormone neuron differentiation
VWFvon Willebrand factorGO: 0007597 blood coagulation, intrinsic pathway;GO: 0072378 blood coagulation, fibrin clot formation;GO: 0002576 platelet degranulation
MMP9Matrix metallopeptidase 9GO: 2000697 negative regulation of epithelial cell differentiation involved in kidney development;GO: 2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO: 0051549 positive regulation of keratinocyte migration
PF4Platelet factor 4GO: 0045651 positive regulation of macrophage differentiation;GO: 0051873 killing by host of symbiont cells;GO: 0045653 negative regulation of megakaryocyte differentiation
GP6Glycoprotein VI plateletGO: 0030168 platelet activation;GO: 0007596 blood coagulation;GO: 0007599 hemostasis

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750