19 August 2020: Database Analysis
Screening and Identification of Potential Peripheral Blood Biomarkers for Alzheimer’s Disease Based on Bioinformatics Analysis
Xin Wang BCD , Lantao Wang AEF*DOI: 10.12659/MSM.924263
Med Sci Monit 2020; 26:e924263
Table 4 Summary of hub genes.
| Symbol | Description | Function |
|---|---|---|
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | GO: 2000386 positive regulation of ovarian follicle development;GO: 0086098 angiotensin-activated signaling pathway involved in heart process;GO: 0001545 primary ovarian follicle growth |
| UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1 | GO: 0035666 TRIF-dependent toll-like receptor signaling pathway;GO: 0070423 nucleotide-binding oligomerization domain containing signaling pathway;GO: 0002756 MyD88-independent toll-like receptor signaling pathway |
| UBB | Ubiquitin B | GO: 0021888 hypothalamus gonadotrophin-releasing hormone neuron development;GO: 0035666 TRIF-dependent toll-like receptor signaling pathway;GO: 0021886 hypothalamus gonadotrophin-releasing hormone neuron differentiation |
| VWF | von Willebrand factor | GO: 0007597 blood coagulation, intrinsic pathway;GO: 0072378 blood coagulation, fibrin clot formation;GO: 0002576 platelet degranulation |
| MMP9 | Matrix metallopeptidase 9 | GO: 2000697 negative regulation of epithelial cell differentiation involved in kidney development;GO: 2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO: 0051549 positive regulation of keratinocyte migration |
| PF4 | Platelet factor 4 | GO: 0045651 positive regulation of macrophage differentiation;GO: 0051873 killing by host of symbiont cells;GO: 0045653 negative regulation of megakaryocyte differentiation |
| GP6 | Glycoprotein VI platelet | GO: 0030168 platelet activation;GO: 0007596 blood coagulation;GO: 0007599 hemostasis |