11 July 2020 : Database Analysis
Underlying Mechanism of Insulin Resistance: A Bioinformatics Analysis Based on Validated Related-Genes from Public Disease Databases
Peng Gao1ACE, Yan Hu1BE, Junyan Wang1BF, Yinghua Ni1C, Zhengyi Zhu1D, Huijuan Wang1C, Jufei Yang1D, Lingfei Huang1F, Luo Fang1AEG*DOI: 10.12659/MSM.924334
Med Sci Monit 2020; 26:e924334
Table 1 Top 10 modules of networks.
| Modules | Score | Nodes | Edges | Node IDs |
|---|---|---|---|---|
| 1 | 57.25 | 99 | 2805 | CCL2, CCR2, ADRA2B, CX3CL1, CX3CR1, PTEN, IL10, EDN1, CASR, SERPINE1, TIMP1, MMP9, INS, MCHR1, PMCH, ADRA2A, TGFB1, MMP1, PYY, SSTR2, SSTR5, VCAM1, CDKN1A, MTNR1A, CSF2, BDKRB2, IGF1, APP, IL6, PTGER3, TP53, CASP3, APLN, CDH1, MAPK14, STAT3, MAPK1, SMAD3, BDNF, CCR5, CCL5, P2RY12, SAA1, ANXA1, AGT, BDKRB1, JUN, NPY2R, NPY, EGFR, SRC, MYC, TNF, CCND1, SPP1, IL4, MTNR1B, CD44, CORT, TNFSF11, IL1B, VEGFA, POMC, GNAI2, ADORA1, MCL1, PTGS2, GAL, AKT1, CXCR4, IL13, HCAR2, HCAR3, CXCL8, HCAR1, TLR4, CXCL5, KRAS, DRD2, TLR2, CNR1, MAPK3, AGTR2, GNB3, IFNG, GPER1, ADCY5, MAPK8, OPRM1, MMP2, CTGF, HGF, MMP3, ERBB2, ICAM1, TNFRSF1A, CXCR3, TLR3, C3 |
| 2 | 32.40 | 115 | 1847 | NGF, ADAM17, IL1A, TXN, TNFSF10, CRP, ADRA1B, FOXP3, RETN, MPO, EDNRA, UTS2, PLAU, UTS2R, PPARG, NLRP3, MIF, ESR1, PARP1, CCK, SIRT1, THBS1, CREB1, AR, CAV1, IL15, CDKN2A, HTR2C, IGF2, CTNNB1, AVP, FFAR4, LGALS3, IL18, CASP1, BCL2L1, IGF1R, FOXO1, IL6R, SOCS3, GNRHR, KISS1, MDM2, HTR2A, HIF1A, RPS6KB1, ARG1, TSC2, ELN, IDO1, HSPA5, HNF4A, MAPK11, CAT, CD40LG, SMAD2, SOD2, NR3C1, ATM, SOCS1, ADRA1A, ADRBK1, MTOR, ADIPOQ, FASLG, REN, XIAP, RAF1, MAPK9, EGF, GPRC6A, PDGFRB, TNFRSF1B, GPT, FOXO3, CDK4, KDR, IL1R1, FAS, CASP8, LEP, IL2, ACE, IL2RA, STAT1, ERBB3, BRCA1, NOS3, RELA, HSP90AA1, HMGB1, HMOX1, GNAQ, IRS1, PTPN11, GHSR, APOE, TERT, NOS2, EGR1, TIMP2, LYN, GZMB, MET, SELL, NFKB1, PGR, EDNRB, IL17A, NFKBIA, SELE, SDC1, CTLA4, STAT5A, JAK2 |
| 3 | 15.72 | 100 | 778 | IGFBP1, SAA4, CDH5, BMP4, ATF3, NOX4, ALK, LTA, WNT5A, AHSG, COL1A1, SPARC, ESR2, SLC2A1, AKT2, CFLAR, APOA4, PLTP, FOXM1, PTPN1, FGB, TF, FGA, AKT3, GSK3B, F5, IRS2, STK11, APOC4, CST3, PLA2G7, PCSK9, LIPC, IL1RN, APOA5, H2AFX, SOD1, SHC1, PTK2, IGFBP7, APOA2, VDR, FGFR1, ALDOA, FGF1, FSTL1, VEGFB, SP1, VTN, TWIST1, VIMP, MEN1, SERPIND1, B2M, APOC1, CTSB, APOC3, NOD2, APOA1, LCAT, MUC1, GGT1, PDGFB, SELP, CD163, TNFRSF11B, AGER, VLDLR, IKBKB, IKBKG, F13A1, RB1, CXCL12, DNMT1, PROC, BCAR1, GAS6, ABCB1, VWF, F8, ABCG2, PGF, ABL1, RET, NFE2L2, NOX1, FGF23, PIK3CA, PIK3R1, HBEGF, AHR, LCN2, TEK, PON1, APOM, CETP, F3, WFS1, CXCL10, CFD |
| 4 | 9.93 | 111 | 546 | GOT2, AGMO, NCOA3, PRLR, MTTP, PIK3CD, RIPK2, GC, NOD1, VAMP2, PLIN1, FGF19, AFP, INSR, PTX3, ACSL1, PLK1, BCL10, ANGPTL3, TGFBR2, DPP4, KRT18, DGKB, KRT8, MAP3K5, CDKN2B, HMGCR, BACE1, ADIPOR2, TSPAN8, HMGA2, ITGB3, BIRC5, BMP7, CDK5, SLC2A4, TH, HSPD1, PIK3CB, ADAMTS9, ELOVL6, NAMPT, HNF1B, MLXIPL, TSC1, UCP2, GDF15, PCK1, AKT1S1, ZFAND6, GCK, RAD51, PDPK1, ADIPOR1, MAF, PLIN2, YWHAZ, SIRT3, CHUK, ACACB, SREBF2, KCNJ11, CPT1A, CTNND1, TGFA, FASN, ACACA, YAP1, CBL, SCD, ARAP1, MAPT, SQSTM1, LIPG, ABCA1, IGFBP3, FADS2, ABCG5, AGTR1, ABCG8, LEPR, E2F1, PTPN6, PIK3C2A, CYP7A1, TGM2, SLC27A4, FABP1, LIPE, ZBED3, GPX1, NOS1, IGF2R, CIDEC, C2CD4B, STUB1, THBD, WT1, GHRL, OLR1, PDGFA, F2, NR4A1, UBE2I, GHR, ELAVL1, KLF14, PIK3CG, GSTP1, SRF, UCP1 |
| 5 | 8.45 | 59 | 245 | ADM, GNAS, PRL, RAC1, SLC27A1, EPHA2, PLAT, SERPINA1, CGA, GPBAR1, UCP3, BGLAP, MC4R, FABP3, PKM, MC3R, PDK4, KLK3, DRD1, IAPP, CEBPA, CPT1B, DGAT2, GLP1R, CD24, BMI1, DGAT1, CYP19A1, PRKCZ, PTK2B, GHRHR, XBP1, TFRC, FABP4, CPT2, CIDEA, CD4, CD36, ADRB1, EIF2AK3, CYBA, TRAF1, ANXA2, LHCGR, FOXA1, GLI1, EPOR, SGK1, FADD, RPS6KA1, ADRB3, GIP, GIPR, ATF4, CHEK2, CRK, BRCA2, TSHR, LMNA |
| 6 | 7.80 | 51 | 195 | NR1H2, HK1, JAZF1, TFAM, NR1H3, APOD, ACSL4, BCL11A, CDKAL1, THADA, SREBF1, CAMK1D, FADS1, SIRT4, YBX1, IL6ST, LPIN1, NR1H4, PRKCB, PRKCD, PNPLA2, GCG, SLC2A2, LPA, GRB10, RBP4, PPARGC1A, HK2, DIO2, ACADVL, CDC123, MSTN, SLC30A8, IGF2BP2, INSIG1, PSEN1, HHEX, BCL2, FTO, SCARB1, LPL, LDLR, INPPL1, GH1, CNTF, FURIN, PRKCA, KCNQ1, COG2, HNF1A, APOB |
| 7 | 5.56 | 51 | 139 | NEDD4, NCOA1, TFAP2B, KCTD15, HTT, PRKAA1, ITGA2B, AGTRAP, CFTR, SEC16B, HP, FGF21, SPRY2, MTCH2, PPARA, NEGR1, PTGS1, FOXA2, GNPDA2, PTGES, TMEM18, AP3B1, PPARD, SNCA, ACSL3, PARK7, CCNC, KSR2, HMGCS1, ITGAV, CBLB, PRKAG3, S100A8, PLA2G4A, MSRA, S100A9, SH2B1, FAIM2, ARNT, ANGPTL4, NR4A2, AGPAT2, MSMO1, LYPLAL1, SYP, CLU, CD14, HMGCS2, NRXN3, PNPLA3, ADRB2 |
| 8 | 5.00 | 5 | 10 | MTRR, MTR, MAT2A, DMGDH, BHMT |
| 9 | 4.14 | 29 | 58 | TXNRD1, PDK1, G6PC2, CYP4A11, ATP5B, ATP5J, H6PD, SLC2A3, TCF7L2, GYS1, ZFAND3, CES1, GFPT2, PLA2G6, GPX3, ATP7A, EPRS, GSTO1, GSTA4, CYP2C19, GCLC, GCKR, PTPRD, PON3, SLC6A4, ABCB11, DBH, CYP2J2, GSTM1 |
| 10 | 4.00 | 4 | 6 | HSD3B1, CYP17A1, SRD5A1, SRD5A2 |