Individualized Running Wheel System with a Dynamically Adjustable Exercise Area and Speed for Rats Following Ischemic Stroke

04 September 2020 : Animal Research

Yu-Lin Wang^123ABC, Jui-Chi Cheng^4AB, Ching-Ping Chang^5BCDE, Fong-Chin Su^1EF*, Chi-Chun Chen^4ABDEFG

DOI: 10.12659/MSM.924411

Med Sci Monit 2020; 26:e924411

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Table 1 Statistical details for behavior tests.

Test	Time points	Sham (n=6)	Control (n=8)	Treadmill (n=8)	MRW (n=8)	DEARW (n=8)
mNSS	Pre-surgery	0.3±0.4	0.3±0.3	0.2±0.4	0.3±0.4	0.2±0.2
	Day 7 post-surgery	0.2±0.3	8.0±0.9^*	6.5±1.8^*	7.2±1.2^*	7.0±0.6^*
	Day 28 post-surgery	0.2±0.4	5.7±0.5^*	3.2±1.2^*	4.5±0.8^*	1.5±0.5^@
Foot fault test (error ratio)	Pre-surgery	0.07±0.04	0.05±0.01	0.06±0.04	0.03±0.02	0.05±0.03
	Day 7 post-surgery	0.05±0.02	0.89±0.12^*	0.73±0.04^*	0.82±0.14^*	0.82±0.15^*
	Day 28 post-surgery	0.04±0.05	0.83±0.12^*	0.73±0.31^*	0.85±0.19^*	0.30±0.12^@
Rotarod-Speed (RPM)	Pre-surgery	28.6±1.6	28.7±1.5	28.2±1.5	29.5±1.4	29.0±1.8
	Day 7 post-surgery	29.3±6.8	17.2±2.3^*	17.7±4.3^*	14.0±4.2^*	12.8±4.8^*
	Day 28 post-surgery	28.8±1.9	17.3±6.9^*	17.0±5.2^*	17.2±2.9^*	25.7±3.4^@
Rotarod-latency (second)	Pre-surgery	250.7±36.7	226.9±57.9	230.1±43.6	242.5±55.4	239.2±60.2
	Day 7 post-surgery	215.2±56.3	89.5±17.0^*	92.9±27.5^*	69.6±27.6^*	61.2±31.3^*
	Day 28 post-surgery	220.2±51.6	92.2±47.6^*	89.8±34.4^*	90.9±18.6^*	185.7±76.9^@
Values are means±S.D. Sham – sham operation; Control – MCAO without rehabilitation; Treadmill – MCAO with treadmill rehabilitation; MRW – MCAO with motorized running wheel (MRW) rehabilitation; DEARW – MCAO with dynamic exercise area running wheel (DEARW) rehabilitation. ^* p ^@ p ^# p ^& p

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